Journal ArticleDOI
Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles
Sanjeev K. Pandey,Dinesh K. Patel,Akhilendra Kumar Maurya,Ravi Thakur,Durga Prasad Mishra,Manjula Vinayak,Chandana Haldar,Pralay Maiti +7 more
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Enhanced DNA cleavage potential, nuclear fragmentation and condensation in apoptotic cells confirm greater bioavailability of PLGA-Tmx as compared to pure Tmx in terms of receptor mediated endocytosis and reveal a novel vehicle for the treatment of cancer.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2016-08-01. It has received 46 citations till now. The article focuses on the topics: PLGA & Fragmentation (cell biology).read more
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Controlled drug delivery vehicles for cancer treatment and their performance.
TL;DR: The different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs are discussed and recent scientific advances in the area of chemotherapy are described.
Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review
TL;DR: The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects.
Journal ArticleDOI
Nanoparticle-mediated targeted drug delivery for breast cancer treatment.
Piumi Y. Liyanage,Sajini D. Hettiarachchi,Yiqun Zhou,Allal Ouhtit,Elif S. Seven,Cagri Oztan,Emrah Celik,Roger M. Leblanc +7 more
TL;DR: A critical analysis of the most recent therapeutic studies involving various NPs-mediated DDS as alternatives for the traditional treatment approaches for BC will shed light on the significance of N Ps- mediated DDS and serve as a guide to seeking for the ideal methodology for future targeted drug delivery for an efficient BC treatment.
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PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide.
TL;DR: The overall result suggests that quercetin and PI3K inhibitor PI-103 attenuatePI3K-AKT pathway in a similar mechanism to reduce detrimental effects of ROS and are recommended as dietary supplements.
Journal ArticleDOI
Quercetin Loaded Nanoparticles in Targeting Cancer: Recent Development.
TL;DR: Various delivery systems of nanoconjugated quercetin like liposomes, silver nanoparticles, PLGA (Poly lactic-co-glycolic acid) and polymeric micelles are described and their potential as promising onco-therapeutic agents in light of recent updates are validated.
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Journal ArticleDOI
Cancer statistics, 2008.
Ahmedin Jemal,Rebecca L. Siegel,Elizabeth Ward,Yongping Hao,Jiaquan Xu,Taylor Murray,Michael J. Thun +6 more
TL;DR: This report examines cancer incidence, mortality, and survival by site, sex, race/ethnicity, education, geographic area, and calendar year, as well as the proportionate contribution of selected sites to the overall trends.
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A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
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A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.
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PLGA-based nanoparticles: An overview of biomedical applications
Fabienne Danhier,Eduardo Ansorena,Joana M. Silva,Joana M. Silva,Régis Coco,Aude Le Breton,Véronique Préat +6 more
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
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Biodegradation and biocompatibility of PLA and PLGA microspheres
TL;DR: This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems, and emphasis is placed on polymer and microSphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres.