Journal ArticleDOI
Cooperative study in the evaluation of therapy in multiple sclerosis. ACTH vs. placebo--final report.
Augustus S. Rose,Jan W. Kuzma,John F. Kurtzke,Norman S. Namerow,William A. Sibley,Wallace W. Tourtellotte +5 more
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This article is published in Neurology.The article was published on 1970-05-01. It has received 252 citations till now. The article focuses on the topics: Placebo & Clinical trial.read more
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Journal ArticleDOI
The current therapy of multiple sclerosis.
TL;DR: The mainstay of treatment for multiple sclerosis in the U.K., and worldwide, remains corticosteroid therapy, and high–dose pulses of intravenous methylprednisolone are currently the most favoured agent for acute exacerbations or a sudden acceleration in clinical course.
Book ChapterDOI
The Effects of Stress on Autoimmune Disease
TL;DR: It has been shown that there is a significant difference in basal adrenocortical activity between male and female Lewis rats, with females exhibiting higher cort levels across most of the 24-hr period.
Journal ArticleDOI
Quantitative benefit-risk assessment of methylprednisolone in multiple sclerosis relapses
TL;DR: High- and low-dose methylprednisolone and the no treatment alternative interchanged as most preferred, contingent on the risk distributions applied for serious adverse effects, the assumed level of risk aversiveness in the patient population, and the relapse severity.
Book ChapterDOI
Prognostic Factors in Intensive Immunosuppressive Treatment of Chronic Progressive MS
TL;DR: Since 1971 a short course of intensive immunosuppression has been induced in 86 chronic progressive multiple sclerosis patients and showed promising results in terms of survival and quality of life.
Journal ArticleDOI
Acthar gel treatment suppresses acute exacerbations in a murine model of relapsing-remitting multiple sclerosis
TL;DR: Acthar treatment ameliorated inflammation/demyelination in the spinal cord and markedly suppressed ex vivo myelin peptide-induced CD4+ T cell proliferation in an animal model of relapsing-remitting MS.
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