Journal ArticleDOI
Cooperative study in the evaluation of therapy in multiple sclerosis. ACTH vs. placebo--final report.
Augustus S. Rose,Jan W. Kuzma,John F. Kurtzke,Norman S. Namerow,William A. Sibley,Wallace W. Tourtellotte +5 more
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This article is published in Neurology.The article was published on 1970-05-01. It has received 252 citations till now. The article focuses on the topics: Placebo & Clinical trial.read more
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Journal ArticleDOI
Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis.
Yuan K. Chou,Dennis Bourdette,Halina Offner,Ruth H. Whitham,Run Ying Wang,George A. Hashim,Arthur A. Vandenbark +6 more
TL;DR: Using the limiting dilution assay, it is demonstrated that the blood of MS patients had an increased frequency of MBP-reactive T cells compared with normal subjects and patients with other neurological diseases (OND) and rheumatoid arthritis.
Journal ArticleDOI
Steroids for multiple sclerosis and optic neuritis: a meta-analysis of randomized controlled clinical trials.
Fabio Brusaferri,Livia Candelise +1 more
TL;DR: Steroid treatment is effective in accelerating short-term recovery in patients with multiple sclerosis or optic neuritis and whether steroids are also effective in reducing the risk of relapse, and the optimal dose and length of treatment must still be determined.
Journal ArticleDOI
Double-blind study of true vs. sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosis.
Howard L. Weiner,Peter C. Dau,Bhupendra O. Khatri,Jack H. Petajan,G. Birnbaum,Michael P. McQuillen,Martin Fosburg,M. Feldstein,E. J. Orav +8 more
TL;DR: PE given with ACTH plus cyclophosphamide enhances recovery from an exacerbation of disease in relapsing/remitting patients, although the authors observed no clear long-term benefits.
Journal ArticleDOI
High-dose glucocorticoids in multiple sclerosis patients exert direct effects on the kidney and skeleton
TL;DR: The theory that high‐dose glucocorticoid administration causes primary depression of bone formation as well as primary effects on the kidney, including lowering the TmP/GFR and increasing 1,25(OH)2D, all before increasing PTH levels is supported.
Journal ArticleDOI
EFNS guideline on treatment of multiple sclerosis relapses: report of an EFNS task force on treatment of multiple sclerosis relapses.
Finn Sellebjerg,David Barnes,G. Filippini,R. Midgard,Xavier Montalban,Peter Rieckmann,Krzysztof Selmaj,Leo H. Visser,Per Soelberg Sørensen +8 more
TL;DR: The objective of the task force was to review the literature on treatment of MS relapses to provide evidence‐based treatment recommendations and there is a need for further randomized, controlled trials in order to establish the optimal treatment regimen for relapses of MS.
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