Journal ArticleDOI
Cooperative study in the evaluation of therapy in multiple sclerosis. ACTH vs. placebo--final report.
Augustus S. Rose,Jan W. Kuzma,John F. Kurtzke,Norman S. Namerow,William A. Sibley,Wallace W. Tourtellotte +5 more
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This article is published in Neurology.The article was published on 1970-05-01. It has received 252 citations till now. The article focuses on the topics: Placebo & Clinical trial.read more
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Journal ArticleDOI
Immunotherapy of multiple sclerosis.
Howard L. Weiner,David A. Hafler +1 more
TL;DR: Given the positive effects of immunotherapy seen thus far in the disease, it is possible that appropriate immunotherapeutic intervention may provide effective treatment for the disease in the future.
Journal ArticleDOI
Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis.
TL;DR: Intravenous steroid followed by oral prednisone was administered to patients with Guillain-Barré syndrome, acute transverse myelitis, and multiple sclerosis in acute relapse to reveal prompt clinical improvement in some patients.
Journal ArticleDOI
Effect of a synthetic polypeptide (COP 1) on patients with multiple sclerosis and with acute disseminated encephalomeylitis. Preliminary report.
TL;DR: Under the treatment with Cop 1, the ADE patients recovered completely within 3 weeks, but 1 of 2 control cases treated with steroids showed complete recovery as well, while the MS patients did not show any significant change in their motor function; however, 2 of them showed some improvement in vision and speech capacity.
Journal ArticleDOI
The history of multiple sclerosis: the changing frame of the disease over the centuries.
TL;DR: In the last fifty years, the major advances have been in basic research to elucidate the mechanisms and processes underlying the disease, the development of imaging techniques (MRI) and theDevelopment of immunomodulatory drugs which, for the first time, are altering the outcome of the disease.
Journal ArticleDOI
The design of clinical studies to assess therapeutic efficacy in multiple sclerosis.
Joe R. Brown,Gilbert W. Beebe,John F. Kurtzke,Ruth B. Loewenson,Donald H. Silberberg,Wallace W. Tourtellotte +5 more
TL;DR: The diagnosis, clinical course, and definitions of the stages of MS are discussed as they relate to trials of therapy, and specific strategies and design considerations be applied to preliminary, pilot, and full trials.
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