Journal ArticleDOI
Cooperative study in the evaluation of therapy in multiple sclerosis. ACTH vs. placebo--final report.
Augustus S. Rose,Jan W. Kuzma,John F. Kurtzke,Norman S. Namerow,William A. Sibley,Wallace W. Tourtellotte +5 more
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This article is published in Neurology.The article was published on 1970-05-01. It has received 252 citations till now. The article focuses on the topics: Placebo & Clinical trial.read more
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Journal ArticleDOI
The long march of the cerebrospinal fluid profile indicative of clinical definite multiple sclerosis; and still marching.
Wallace W. Tourtellotte,Wallace W. Tourtellotte,R.W. Baumhefner,R.W. Baumhefner,Karl Syndulko,Karl Syndulko,Paul Shapshak,Paul Shapshak,M. Osborne,G. Rubinstein,L. Newton,George W. Ellison,Lawrence W. Myers,I.P. Rosario,R.V. Thomsen,R. Sloan,S. Engelmann +16 more
TL;DR: It is believed that intra-BBB IgG synthesis is caused by a persistent antigen, most likely a virus, possibly measles, and is present in almost every case of clinical definite MS in a chronic progressive phase.
Journal ArticleDOI
Disease-modifying therapies for multiple sclerosis
TL;DR: Patients at high risk of developing RRMS after CIS achieve significant benefit after treatment with IFNβ-1a, and initiation of therapy after CIS should be given strong consideration, and it is justifiable to treat SPMS patients withIFNβ.
Journal ArticleDOI
Effect of methylprednisolone on CSF IgG parameters, myelin basic protein and anti-myelin basic protein in multiple sclerosis exacerbations.
TL;DR: Whether anti-MBP antibodies are present in increased titer in CSF of MS patients with exacerbations, and whether they can be suppressed by the administration of immunosuppressive dosages of methylprednisolone (MP), and how these levels are reduced by IV-MP.
Journal ArticleDOI
A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis.
M C Hoogstraten,J. M. Minderhoud +1 more
TL;DR: It is thought that to obtain useful information on the mechanism of post-ictal headache, further studies should be performed taking into consideration seizure physiopathology and completed by neuroendocrinological and neurophysiological findings.
Journal ArticleDOI
Multiple Sclerosis Therapy : A Practical Guide
TL;DR: A growing amount of evidence suggests that a disturbance of immunological function is of importance in the pathogenesis of multiple sclerosis as discussed by the authors, which is reflected in the drugs used to slow progression and to treat relapses.
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