Coronavirus Disease (COVID-19): Current Status and Prospects for Drug and Vaccine Development.
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TLDR
This review focuses on the drugs and vaccines being developed against the COVID-19, a pandemic that has spread to almost all nooks and corners of the world.Citations
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COVID-19: Characteristics and Therapeutics.
TL;DR: In this paper, the authors present a succinct overview of the SARS-CoV-2 virus structure, molecular mechanisms of infection, COVID-19 epidemiology, diagnosis, and clinical manifestations, and systematize different treatment strategies and clinical trials initiated after the pandemic outbreak, based on viral infection and replication mechanisms.
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Current Strategies of Antiviral Drug Discovery for COVID-19
TL;DR: Li et al. as discussed by the authors discuss the current status of the drug discovery efforts against COVID-19 and potential future directions and discuss the need to identify new treatment strategies for viral infections.
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Potential therapeutic agents to COVID-19: An update review on antiviral therapy, immunotherapy, and cell therapy.
Mona Sadat Mirtaleb,Amir Hossein Mirtaleb,Hassan Nosrati,Jalal Heshmatnia,Reza Falak,Reza Zolfaghari Emameh +5 more
TL;DR: In this paper, the authors introduce the present and potential future treatment strategies against COVID-19 and define the advantages and disadvantages of each treatment strategy, including nanomedicine, immunotherapy, and cell therapy.
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Metal Complexes as Antiviral Agents for SARS-CoV-2.
Johannes Karges,Seth M. Cohen +1 more
TL;DR: In this article, the metal complexes that have been reported to show antiviral activity against SARS-CoV-2 or one of its target proteins are described and their proposed mechanisms of action are discussed.
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COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges
Kuldeep Dhama,Manish Dhawan,Ruchi Tiwari,Talha Bin Emran,Saikat Mitra,Ali A. Rabaan,Saad Alhumaid,Zainab Al Alawi,Abbas Al Mutair +8 more
TL;DR: The current progress, advantages, prospects, and challenges in developing intranasal COVID-19 vaccines for countering the ongoing pandemic are highlighted.
References
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Enzymatic assembly of DNA molecules up to several hundred kilobases
Daniel G. Gibson,Lei Young,Ray-Yuan Chuang,J. Craig Venter,Clyde A. Hutchison,Hamilton O. Smith +5 more
TL;DR: An isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5′ exonuclease, a DNA polymerase and a DNA ligase is described.
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.
TL;DR: Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough, and bilateral lung involvement with ground-glass opacity was themost common finding from computed tomography images of the chest.
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Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2.
TL;DR: Cryo–electron microscopy structures of full-length human ACE2 in the presence of the neutral amino acid transporter B0AT1 with or without the receptor binding domain (RBD) of the surface spike glycoprotein of SARS-CoV-2 are presented, providing important insights into the molecular basis for coronavirus recognition and infection.
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COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses
Muhammad Adnan Shereen,Muhammad Adnan Shereen,Suliman Khan,Abeer Kazmi,Nadia Bashir,Rabeea Siddique +5 more
TL;DR: The approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak are discussed and the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory virus (MERS- coV) is analyzed.
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mRNA vaccines — a new era in vaccinology
TL;DR: A detailed overview of mRNA vaccines is provided and future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use are considered.