Open Access
Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish
Nicolas Rohner,Daniel F. Jarosz,Johanna E. Kowalko,Masato Yoshizawa,William R. Jeffery,William R. Jeffery,Richard Borowsky,Susan Lindquist,Susan Lindquist,Clifford J. Tabin +9 more
TLDR
In this article, heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus, resulting in reduced-eye phenotype even in the presence of full HSP90 activity.Abstract:
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that heat shock protein 90 (HSP90) phenotypically masks standing eye-size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as does direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting.read more
Citations
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Journal ArticleDOI
The HSP90 chaperone machinery
TL;DR: Owing to the importance of HSP90 in the regulation of many cellular proteins, it has become a promising drug target for the treatment of several diseases, which include cancer and diseases associated with protein misfolding.
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Cryptic genetic variation: evolution's hidden substrate
TL;DR: The empirical support for widespread CGV in natural populations is reviewed, including its potential role in emerging human diseases and the growing evidence of its contribution to evolution are reviewed.
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Evaluating 'Plasticity-First' Evolution in Nature: Key Criteria and Empirical Approaches
TL;DR: The goal is to provide a means by which the role of plasticity in adaptive evolution can be assessed and present much-needed key criteria to allow tests in diverse, natural systems.
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Eco-Evo-Devo: developmental symbiosis and developmental plasticity as evolutionary agents
TL;DR: The roles that developmental symbiosis and developmental plasticity have in evolution are highlighted and Eco-Evo-Devo presents a new layer of evolutionary synthesis.
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Exonic transcription factor binding directs codon choice and affects protein evolution
Andrew B. Stergachis,Eric Haugen,Anthony Shafer,Wenqing Fu,Benjamin Vernot,Alex Reynolds,Anthony Raubitschek,Anthony Raubitschek,Steven F. Ziegler,Emily M LeProust,Joshua M. Akey,John A. Stamatoyannopoulos +11 more
TL;DR: It is found that ~15% of human codons are dual-use codons (“duons”) that simultaneously specify both amino acids and TF recognition sites, and TF-imposed constraint appears to be a major driver of codon usage bias.
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