Journal ArticleDOI
Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signaling.
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TLDR
Curcumin treatment attenuates LPS-induced PI3K/AKT and CYP2E/Nrf2/ROS signaling and liver injury and strategies to inhibit inflammation and apoptosis signaling may provide alternatives to the current clinical approaches to improve oxidative responses of endotoxemia.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2016-10-01. It has received 191 citations till now. The article focuses on the topics: Protein kinase B & Oxidative stress.read more
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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications.
Javad Sharifi-Rad,Youssef El Rayess,Alain Abi Rizk,Carmen Sadaka,Raviella Zgheib,Wissam Zam,Simona Sestito,Simona Rapposelli,Katarzyna Neffe-Skocińska,Dorota Zielińska,Bahare Salehi,William N. Setzer,Noura S. Dosoky,Yasaman Taheri,Marc El Beyrouthy,Miquel Martorell,Elise Adrian Ostrander,Hafiz Ansar Rasul Suleria,William C. Cho,Alfred Maroyi,Natália Martins +20 more
TL;DR: This review aims to offer an in-depth discussion of curcumin applications for food and biotechnological industries, and on health promotion and disease prevention, with particular emphasis on its antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, and cardioprotective effects.
Journal ArticleDOI
Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective
Mohammad Hosein Farzaei,Mahdi Zobeiri,Fatemeh Parvizi,Fardous F. El-Senduny,Ilias Marmouzi,Ericsson Coy-Barrera,Rozita Naseri,Seyed Mohammad Nabavi,Roja Rahimi,Mohammad Abdollahi +9 more
TL;DR: Electronic databases were extensively searched and results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms.
Journal ArticleDOI
Sepsis: Inflammation Is a Necessary Evil.
TL;DR: An argument for a proper understanding of the molecular basis of inflammation as well as apoptosis for developing an effective therapy is put forth.
Journal ArticleDOI
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation
Lifa Huang,Chengwei Chen,Xin Zhang,Xu Li,Zupeng Chen,Chao Yang,Xiaolong Liang,Guo-Chong Zhu,Zhen Xu +8 more
TL;DR: Curcumin exerts neuroprotective effects by attenuating autophagic activities through mediating the PI3K/Akt/mTOR pathway, while also suppressing an inflammatory reaction by regulating the TLR4/p38/MAPK pathway and indicates that curcumin could be an effective therapy for patients afflicted with ischemia.
Journal ArticleDOI
Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress.
TL;DR: This review summarizes current understanding of the dynamic interplay between oxidative stress and antioxidants and discusses compelling preclinical evidence that bioactive plant-derived compounds can be both safe and effective for managing both iron deficiency and iron overload conditions.
References
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NF-κB, inflammation, and metabolic disease.
TL;DR: It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases, and numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology.
Journal ArticleDOI
Oxidative stress in bacteria and protein damage by reactive oxygen species.
TL;DR: This paper reviews major key points in the generation of reactive oxygen species in bacteria, defense mechanisms and genetic responses to oxidative stress, with special attention to oxidative damage to proteins.
Journal ArticleDOI
Mitochondrial oxidative stress: implications for cell death.
TL;DR: These findings have placed the mitochondria in the focus of current cell death research and highlighted the importance of understanding the mechanisms behind mitochondrial regulation of apoptosis.
Journal ArticleDOI
Chronic stress and age-related increases in the proinflammatory cytokine IL-6.
Janice K. Kiecolt-Glaser,Kristopher J. Preacher,Robert C. MacCallum,Cathie Atkinson,William B. Malarkey,Ronald Glaser +5 more
TL;DR: Evidence is provided of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response.
Journal ArticleDOI
Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress: A Possible Factor in Human Early Pregnancy Failure
Eric Jauniaux,Adrian L. Watson,Joanne Hempstock,Yi-Ping Bao,Jeremy N. Skepper,Graham J. Burton +5 more
TL;DR: In this article, the authors measured changes in the oxygen tension within the human placenta associated with onset of the maternal arterial circulation at the end of the first trimester of pregnancy, and the impact on placental tissues.
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