Current EU research activities on combined exposure to multiple chemicals
Stephanie K. Bopp,Robert Barouki,Werner Brack,Silvia Dalla Costa,Jean-Lou Dorne,Paula E. Drakvik,Michael Faust,Tuomo K. Karjalainen,Stylianos Kephalopoulos,Jacob D. van Klaveren,Marike Kolossa-Gehring,Andreas Kortenkamp,Erik Lebret,Teresa Lettieri,Sofie Nørager.,Joëlle Rüegg,Jose Tarazona,Xenia Trier,Bob van de Water,Jos van Gils,Åke Bergman,Åke Bergman +21 more
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This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.About:
This article is published in Environment International.The article was published on 2018-08-28 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Environmental exposure & European union.read more
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Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals
Simon J. More,Vasileios Bampidis,Diane Benford,Susanne Hougaard Bennekou,Claude Bragard,Thorhallur I. Halldorsson,Antonio F Hernandez-Jerez,Konstantinos Koutsoumanis,Hanspeter Naegeli,Josef Rudolf Schlatter,Vittorio Silano,Søren Saxmose Nielsen,Dieter Schrenk,Dominique Turck,Maged Younes,Emilio Benfenati,Laurence Castle,Nina Cedergreen,Anthony Hardy,Ryszard Laskowski,Jean-Charles Leblanc,Andreas Kortenkamp,Ad M.J. Ragas,Leo Posthuma,Claus Svendsen,Roland Solecki,Emanuela Testai,Bruno Dujardin,George E.N. Kass,Paola Manini,Maryam Zare Jeddi,Jean Lou Cm Dorne,Christer Hogstrand +32 more
TL;DR: This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas.
Journal ArticleDOI
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.
Elina Drakvik,Elina Drakvik,Rolf Altenburger,Yasunobu Aoki,Thomas Backhaus,Tina Bahadori,Robert Barouki,Werner Brack,Mark T. D. Cronin,Barbara A. Demeneix,Susanne Hougaard Bennekou,Jacob D. van Klaveren,Carsten Kneuer,Marike Kolossa-Gehring,Erik Lebret,Leo Posthuma,Lena Reiber,Cynthia V. Rider,Joëlle Rüegg,Giuseppe Testa,Bart van der Burg,Hilko van der Voet,A. Michael Warhurst,Bob van de Water,Kunihiko Yamazaki,Mattias Öberg,Åke Bergman +26 more
TL;DR: It is argued that a European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures, as well as research to address regulatory and policy needs.
Journal ArticleDOI
Regulatory assessment and risk management of chemical mixtures: challenges and ways forward.
Stephanie K. Bopp,Aude Kienzler,Andrea-Nicole Richarz,Sander van der Linden,Alicia Paini,Nikolaos Parissis,Andrew Worth +6 more
TL;DR: Considering the large number of possible combinations of chemicals in mixtures, prioritization is needed, so that actions first address mixtures of highest concern and chemicals that drive the mixture risk.
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Proposing new approaches for the risk characterisation of single chemicals and chemical mixtures: The source related Hazard Quotient (HQS) and Hazard Index (HIS) and the adversity specific Hazard Index (HIA).
TL;DR: An analysis based on the individual critical effects is presented, in order to derive the critical effect and an adversity specific Hazard Index (HIA) and risk characterisation for the whole mixture.
Journal ArticleDOI
Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution.
S. Rotter,Anna Beronius,Alan R. Boobis,Annika Hanberg,J. van Klaveren,Mirjam Luijten,K Machera,D Nikolopoulou,H. van der Voet,Johanna Zilliacus,Roland Solecki +10 more
TL;DR: The Horizon 2020 project “EuroMix” aims to contribute to the further development of internationally harmonized approaches for such risk assessments by the development of an integrated test strategy using in vitro and in silico tests verified for chemical mixtures based on more appropriate data on potential combined effects.
References
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R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Organic chemicals jeopardize the health of freshwater ecosystems on the continental scale
Egina Malaj,Egina Malaj,Peter C. von der Ohe,Matthias Grote,Ralph Kühne,Cédric P. Mondy,Philippe Usseglio-Polatera,Werner Brack,Ralf B. Schäfer +8 more
TL;DR: It is provided strong evidence that chemicals threaten the ecological integrity and consequently the biodiversity of almost half of the water bodies on a continental scale, based on the analysis of governmental monitoring data from 4,000 European sites.
Journal ArticleDOI
Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go?
TL;DR: Development of mass spectrometers with increasingly high resolution and novel couplings to both liquid and gas chromatography, combined with the integration of high performance computing, have significantly widened the authors' analytical window and have enabled increasingly sophisticated data processing strategies, indicating a bright future for NTS.
Journal ArticleDOI
Complex mixture toxicity for single and multiple species: Proposed methodologies
Dick de Zwart,Leo Posthuma +1 more
TL;DR: Using comparable mixture toxicity strategies in combination with the concept of species-sensitivity distributions, a method to address and predict the risk for direct effects on the composition of species assemblages and biodiversity is developed.
Journal ArticleDOI
Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework.
M.E. Bette Meek,Alan R. Boobis,Kevin M. Crofton,Gerhard Heinemeyer,Marcel Van Raaij,Carolyn Vickers +5 more
TL;DR: A framework for the risk assessment of combined exposure to multiple chemicals based on and developed subsequent to the World Health Organization/International Programme on Chemical Safety Workshop on Aggregate/Cumulative Risk Assessment (Combined Exposures to Multiple Chemicals) held in 2007 is described.
Related Papers (5)
Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals
Simon J. More,Vasileios Bampidis,Diane Benford,Susanne Hougaard Bennekou,Claude Bragard,Thorhallur I. Halldorsson,Antonio F Hernandez-Jerez,Konstantinos Koutsoumanis,Hanspeter Naegeli,Josef Rudolf Schlatter,Vittorio Silano,Søren Saxmose Nielsen,Dieter Schrenk,Dominique Turck,Maged Younes,Emilio Benfenati,Laurence Castle,Nina Cedergreen,Anthony Hardy,Ryszard Laskowski,Jean-Charles Leblanc,Andreas Kortenkamp,Ad M.J. Ragas,Leo Posthuma,Claus Svendsen,Roland Solecki,Emanuela Testai,Bruno Dujardin,George E.N. Kass,Paola Manini,Maryam Zare Jeddi,Jean Lou Cm Dorne,Christer Hogstrand +32 more