Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals
Simon J. More,Vasileios Bampidis,Diane Benford,Susanne Hougaard Bennekou,Claude Bragard,Thorhallur I. Halldorsson,Antonio F Hernandez-Jerez,Konstantinos Koutsoumanis,Hanspeter Naegeli,Josef Rudolf Schlatter,Vittorio Silano,Søren Saxmose Nielsen,Dieter Schrenk,Dominique Turck,Maged Younes,Emilio Benfenati,Laurence Castle,Nina Cedergreen,Anthony Hardy,Ryszard Laskowski,Jean-Charles Leblanc,Andreas Kortenkamp,Ad M.J. Ragas,Leo Posthuma,Claus Svendsen,Roland Solecki,Emanuela Testai,Bruno Dujardin,George E.N. Kass,Paola Manini,Maryam Zare Jeddi,Jean Lou Cm Dorne,Christer Hogstrand +32 more
Reads0
Chats0
TLDR
This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas.Abstract:
This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals for all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis for combined exposure risk assessment and approaches to assessing (eco)toxicology is given, including existing frameworks for these risk assessments. This background was evaluated, resulting in a harmonised framework for risk assessment of combined exposure to multiple chemicals. The framework is based on the risk assessment steps (problem formulation, exposure assessment, hazard identification and characterisation, and risk characterisation including uncertainty analysis), with tiered and stepwise approaches for both whole mixture approaches and component-based approaches. Specific considerations are given to component-based approaches including the grouping of chemicals into common assessment groups, the use of dose addition as a default assumption, approaches to integrate evidence of interactions and the refinement of assessment groups. Case studies are annexed in this guidance document to explore the feasibility and spectrum of applications of the proposed methods and approaches for human and animal health and ecological risk assessment. The Scientific Committee considers that this Guidance is fit for purpose for risk assessments of combined exposure to multiple chemicals and should be applied in all relevant areas of EFSA's work. Future work and research are recommended.read more
Citations
More filters
Journal ArticleDOI
Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited 'FAO estimate' of 25.
Mari Eskola,Gregor Kos,Christopher T. Elliott,Jana Hajslova,Sultan Mayar,Rudolf Krska,Rudolf Krska +6 more
TL;DR: Current mycotoxin occurrenceabove the EU and Codex limits appears to confirm the FAO 25% estimate, while this figure greatly underestimates the occurrence above the detectable levels (up to 60–80%).
Journal ArticleDOI
Risk to human health related to the presence of perfluoroalkyl substances in food
Dieter Schrenk,Margherita Bignami,Laurent Bodin,James K. Chipman,Jesús del Mazo,Bettina Grasl-Kraupp,Christer Hogstrand,Laurentius Hoogenboom,Jean-Charles Leblanc,Carlo Nebbia,Elsa Nielsen,Evangelia E. Ntzani,Annette Petersen,Salomon Sand,Christiane Vleminckx,Heather M. Wallace,Lars Barregard,Sandra Ceccatelli,Jean-Pierre Cravedi,Thorhallur I. Halldorsson,Line Småstuen Haug,Niklas Johansson,Helle Katrine Knutsen,Martin Rose,Alain-Claude Roudot,Henk Van Loveren,Günter Vollmer,Karen Mackay,Francesca Riolo,Tanja Schwerdtle +29 more
TL;DR: The CONTAM Panel concluded that parts of the European population exceed this tolerable weekly intake (TWI) of 4.4 ng/kg bw per week, which is of concern, and protects against other potential adverse effects observed in humans.
Journal ArticleDOI
Bisphenol A and its analogs in muscle and liver of fish from the North East Atlantic Ocean in relation to microplastic contamination. Exposure and risk to human consumers
Luís Gabriel Antão Barboza,Sara C. Cunha,Carolina Monteiro,José O. Fernandes,Lúcia Guilhermino +4 more
TL;DR: The levels of bisphenol A (BPA) and analagous compounds in muscle and liver of fish from the North East Atlantic Ocean were determined and the risk of their consumption by humans was assessed, suggesting hazardous risk for human consumers.
Journal ArticleDOI
Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials
Vittorio Silano,José Manuel Barat Baviera,Claudia Bolognesi,Andrew Chesson,Pier Sandro Cocconcelli,Riccardo Crebelli,David Michael Gott,Konrad Grob,Evgenia Lampi,Alicja Mortensen,Gilles Rivière,Inger-Lise Steffensen,Christina Tlustos,Henk Van Loveren,Laurence Vernis,Holger Zorn,Jean-Pierre Cravedi,Cristina Fortes,Maria de Fátima Tavares Poças,Ine Waalkens-Berendsen,Detlef Wölfle,Davide Arcella,Claudia Cascio,Anna F. Castoldi,Katharina Volk,Laurence Castle +25 more
TL;DR: The CEP Panel considered that the current assessment of the five phthalates, individually and collectively, should be on a temporary basis because of the limited scope of the mandate and the uncertainties identified.
Journal ArticleDOI
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.
Elina Drakvik,Elina Drakvik,Rolf Altenburger,Yasunobu Aoki,Thomas Backhaus,Tina Bahadori,Robert Barouki,Werner Brack,Mark T. D. Cronin,Barbara A. Demeneix,Susanne Hougaard Bennekou,Jacob D. van Klaveren,Carsten Kneuer,Marike Kolossa-Gehring,Erik Lebret,Leo Posthuma,Lena Reiber,Cynthia V. Rider,Joëlle Rüegg,Giuseppe Testa,Bart van der Burg,Hilko van der Voet,A. Michael Warhurst,Bob van de Water,Kunihiko Yamazaki,Mattias Öberg,Åke Bergman +26 more
TL;DR: It is argued that a European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures, as well as research to address regulatory and policy needs.
References
More filters
Journal ArticleDOI
The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Martin van den Berg,Linda S. Birnbaum,Michael S. Denison,Mike De Vito,William H. Farland,Mark Feeley,Heidelore Fiedler,Helen Håkansson,Annika Hanberg,Laurie C. Haws,Martin Rose,Stephen Safe,Dieter Schrenk,Chiharu Tohyama,Angelika Tritscher,Jouko Tuomisto,Mats Tysklind,Nigel J. Walker,Richard E. Peterson +18 more
TL;DR: Concern was expressed about direct application of the TEF/total toxic equivalency (TEQ) approach to abiotic matrices, such as soil, sediment, etc., for direct application in human risk assessment as the present TEF scheme and TEQ methodology are primarily intended for estimating exposure and risks via oral ingestion.
Journal ArticleDOI
Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
Gerald T. Ankley,Richard S. Bennett,Russell J. Erickson,Dale J. Hoff,Michael W. Hornung,Rodney D. Johnson,David R. Mount,John W. Nichols,Christine L. Russom,Patricia K. Schmieder,Jose A. Serrrano,Joseph E. Tietge,Daniel L. Villeneuve +12 more
TL;DR: A framework designed for this purpose, the adverse outcome pathway (AOP), is discussed, a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment.
Journal ArticleDOI
The toxicity of poisons applied jointly1
TL;DR: A quantitative analysis of the toxicity of drugs or poisons applied jointly requires that they be administered at several dosages in mixtures containing fixed proportions of the ingredients, and the presence of synergism is indicated.
Journal Article
The search for synergy: a critical review from a response surface perspective.
W R Greco,G Bravo,J C Parsons +2 more
Journal ArticleDOI
Neonicotinoid Pesticide Reduces Bumble Bee Colony Growth and Queen Production
TL;DR: Given the scale of use of neonicotinoid insecticides, it is suggested that they may be having a considerable negative impact on wild bumble bee populations across the developed world.
Related Papers (5)
Guidance on the assessment of the safety of feed additives for the consumer.
Efsa Panel on Additives,Guido Rychen,Gabriele Aquilina,Giovanna Azimonti,Vasileios Bampidis,Maria de Lourdes Bastos,Georges Bories,Andrew Chesson,Pier Sandro Cocconcelli,Gerhard Flachowsky,Jürgen Gropp,Boris Kolar,Maryline Kouba,Marta López-Alonso,Secundino López Puente,Alberto Mantovani,Baltasar Mayo,Fernando Ramos,Maria Saarela,Roberto Edoardo Villa,Robert John Wallace,Pieter Wester,Montserrat Anguita,Bruno Dujardin,Jaume Galobart,Matteo Lorenzo Innocenti +25 more
Guidance on the assessment of the safety of feed additives for the target species
Efsa Panel on Additives,Guido Rychen,Gabriele Aquilina,Giovanna Azimonti,Vasileios Bampidis,Maria de Lourdes Bastos,Georges Bories,Andrew Chesson,Pier Sandro Cocconcelli,Gerhard Flachowsky,Jürgen Gropp,Boris Kolar,Maryline Kouba,Marta López-Alonso,Secundino López Puente,Alberto Mantovani,Baltasar Mayo,Fernando Ramos,Maria Saarela,Roberto Edoardo Villa,Robert John Wallace,Pieter Wester,Montserrat Anguita,Jaume Galobart,Matteo Lorenzo Innocenti,Laura Martino +25 more
Quantifying Synergy: A Systematic Review of Mixture Toxicity Studies within Environmental Toxicology
Guidance on the identity, characterisation and conditions of use of feed additives.
Guido Rychen,Gabriele Aquilina,Giovanna Azimonti,Vasileios Bampidis,Maria de Lourdes Bastos,Georges Bories,Andrew Chesson,Pier Sandro Cocconcelli,Gerhard Flachowsky,Jürgen Gropp,Boris Kolar,Maryline Kouba,Marta López-Alonso,Secundino López Puente,Alberto Mantovani,Baltasar Mayo,Fernando Ramos,Maria Saarela,Roberto Edoardo Villa,Robert John Wallace,Pieter Wester,Montserrat Anguita,Jaume Galobart,Matteo Lorenzo Innocenti +23 more