Journal ArticleDOI
Current strategies towards hemocompatible coatings
TLDR
Inorganic coatings were shown to substantially improve the durability and inertness of biomaterials while a number of advanced polymer Coatings were demonstrated to be very effective by targeting specific biochemical pathways.Abstract:
A wide range of biomedical devices is applied clinically in contact with blood. Tailoring the surface properties of the involved biomaterials is a common approach to enhance performance and to limit adverse reactions. This review summarizes current trends in coating technologies developed for that purpose. Inorganic coatings were shown to substantially improve the durability and inertness of biomaterials while a number of advanced polymer coatings were demonstrated to be very effective by targeting specific biochemical pathways. However, to fully utilize the power of these bioactive coatings safety issues need to be thoroughly addressed in future studies.read more
Citations
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Advances in polymers for anti-biofouling surfaces
TL;DR: In this paper, a review highlights recent advances in the design and synthesis of polymers that can resist fouling by biomolecules, cells and organisms, and the mechanisms of anti-biofouling activity is discussed.
Journal ArticleDOI
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling
Daniel C. Leslie,Anna Waterhouse,Julia B Berthet,Julia B Berthet,Julia B Berthet,Thomas M. Valentin,Alexander Watters,Alexander Watters,Abhishek Jain,Philseok Kim,Benjamin Hatton,Benjamin Hatton,Benjamin Hatton,Arthur Nedder,Kathryn Donovan,Elana H. Super,Caitlin Howell,Caitlin Howell,Christopher P Johnson,Christopher P Johnson,Thy L. Vu,Thy L. Vu,Dana Bolgen,Sami A. Rifai,Anne Hansen,Michael Aizenberg,Michael Super,Michael Super,Michael Super,Joanna Aizenberg,Donald E. Ingber +30 more
TL;DR: A bioinspired, omniphobic coating is applied to tubing and catheters and it is shown that it completely repels blood and suppresses biofilm formation, which could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
Journal ArticleDOI
Fundamental Theory of Biodegradable Metals—Definition, Criteria, and Design
Yang Liu,Yufeng Zheng,Xie-Hui Chen,Jian-An Yang,Haobo Pan,Dafu Chen,Luning Wang,Jialiang Zhang,Donghui Zhu,Shuilin Wu,Kelvin W.K. Yeung,Rong-Chang Zeng,Yong Han,Shaokang Guan +13 more
TL;DR: In this article, the dual criteria of biodegradability and biocompatibility are proposed for BMs, and all metallic elements in the periodic table with accessible data are screened on the basis of these criteria.
Journal ArticleDOI
Surface chemistry to minimize fouling from blood-based fluids
TL;DR: The surface chemistry developed to date to minimize fouling from these considerably more challenging blood-based fluids is summarized and adsorption dynamics is discussed.
Journal ArticleDOI
Blood coagulation on biomaterials requires the combination of distinct activation processes
Claudia Sperling,Marion Fischer,Manfred F. Maitz,Carsten Werner,Carsten Werner,Carsten Werner +5 more
TL;DR: The results reveal that contact activation and platelet adhesion have a strong synergistic effect on coagulation on blood-contacting materials even though these events in isolation are not sufficient to induce substantial thrombin formation.
References
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Journal ArticleDOI
The surface science of titanium dioxide
TL;DR: Titanium dioxide is the most investigated single-crystalline system in the surface science of metal oxides, and the literature on rutile (1.1) and anatase surfaces is reviewed in this paper.
Journal ArticleDOI
Light-induced amphiphilic surfaces
Rong Wang,Kazuhito Hashimoto,Akira Fujishima,Makota Chikuni,Eiichi Kojima,Atsushi Kitamura,Mitsuhide Shimohigoshi,Toshiya Watanabe +7 more
TL;DR: In this paper, the photogeneration of a highly amphiphilic (both hydrophilic and oleophilic) titanium dioxide surface was reported, and the unique character of this surface was ascribed to the microstructured composition of hydrophilicity of the phases, produced by ultraviolet irradiation.
Journal ArticleDOI
Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes
Maud B. Gorbet,Michael V. Sefton +1 more
TL;DR: Current perspectives on all four of these components in thrombosis and with biomaterials and cardiovascular devices are summarized.
Journal ArticleDOI
Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.
TL;DR: Cl clot-bound thrombin is relatively protected from inhibition by heparin, and antithrombin III-independent inhibitors may be more effective than hepar in certain clinical settings.
Journal ArticleDOI
The VIVA Trial Vascular Endothelial Growth Factor in Ischemia for Vascular Angiogenesis
Timothy D. Henry,Brian H. Annex,George R. McKendall,Michael Azrin,John J. Lopez,Frank J. Giordano,Prediman K. Shah,James T. Willerson,Raymond L. Benza,Daniel S. Berman,C. Michael Gibson,Alex Bajamonde,Amy Chen Rundle,J. T. Fine,Edward R. McCluskey +14 more
TL;DR: The VIVA (Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis) trial as discussed by the authors was designed to evaluate the safety and efficacy of intracoronary and intravenous infusions of rhVEGF.
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