Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
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TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
Citations
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Dissertation
Polymeric Systems for Transscleral Delivery of Antisense Oligonucleotides: A Novel Treatment Strategy for Age-Related Macular Degeneration
TL;DR: Using nanofiltration membranes for the recovery of phosphorous with a second type of technology for the Recovery of nitrogen is suggest to be a viable process.
Journal ArticleDOI
Dendrimer-based delivery of macromolecules for the treatment of brain tumor.
Hira Choudhury,Manisha Pandey,Raxshanaa Mohgan,J. Jong,Roshini Nicole David,Wan Yi Ngan,Tze Liang Chin,Shereen Ting,Prashant Kesharwani,Bapi Gorain +9 more
TL;DR: In this paper , a review on therapeutic applications of dendrimer platforms in brain tumor treatment is presented, where a focus has been made on the application of Dendrimers as a potential platform for nucleic acid and peptide delivery and its promising clinical application could provide effective and target-specific treatment against brain tumors.
Dendrimer: a new approach in pharmacy
TL;DR: Synthesis of dendrimer- drug complexes can act novel method for improving bioavailability and enhance the therapeutic effect of the drug with less toxicity as improvement of solubility.
Book ChapterDOI
3.20 Molecular Imaging
S.H. Crayton,Antony K. Chen,Jessica F. Liu,Elizabeth Higbee-Dempsey,C.-H. Huang,Andrew Tsourkas,Zhiliang Cheng +6 more
TL;DR: This chapter describes several of the materials commonly used to construct molecular imaging probes and particular attention is paid to the material properties crucial for generating contrast on medical imaging systems and the interactions between these materials and biological systems.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
Related Papers (5)
Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more