Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
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TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
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Dendrimer advances for the central nervous system delivery of therapeutics.
Leyuan Xu,Hao Zhang,Yue Wu +2 more
TL;DR: The latest applications of dendrimers in the treatment of CNS diseases with an emphasis on brain tumors are discussed and the toxicity, biodistribution, and transport mechanisms in d endrimer-mediated delivery of CNS therapeutic agents bypassing or crossing the blood-brain barrier are discussed.
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Nanotechnology for bone materials.
Nhiem Tran,Thomas J. Webster +1 more
TL;DR: This review summarizes studies that have demonstrated enhanced in vitro and in vivo osteoblast functions on nanostructured metals, ceramics, polymers, and composites thereof compared to currently used implants, suggesting that nanomaterials may improve osseointegration, which is crucial for long-term implant efficacy.
Journal ArticleDOI
Antibacterial activity and cytotoxicity of PEGylated poly(amidoamine) dendrimers
TL;DR: The cytotoxicity of the PEGylated dendrimers to host cells is much lower than that reported for antimicrobial peptides, and the MICs of these d endrimers against P. aeruginosa are more than two orders of magnitude lower than other antimicrobial polymers reported to date.
Journal ArticleDOI
Dendrimer-based nanocarriers: a versatile platform for drug delivery.
TL;DR: This review provides a comprehensive overview of the commonly employed dendrimer-based nanocarrier designs, including dendedrimer conjugates, Janus d endrimers, and linear-dendritic block copolymers, with the aim of providing researchers in the drug delivery field a good understanding of the potential utilities.
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A synthetic "tour de force": well-defined multivalent and multimodal dendritic structures for biomedical applications.
TL;DR: This Minireview outlines the different available synthetic strategies, some applications that already make use of this new generation of multivalent and multimodal architectures, and the challenges for future developments.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
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The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
Related Papers (5)
Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more