Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
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TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
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Study of a potential drug delivery system based on carbon nanoparticles: effects of fullerene derivatives in MCF7 mammary carcinoma cells
Marianna Lucafò,Sabrina Pacor,Chiara Fabbro,Tatiana Da Ros,Sonia Zorzet,Maurizio Prato,Gianni Sava +6 more
TL;DR: A strong interaction between the tested fullerene and mammalian cells and a significant ability of this compound to enter tumor cells are suggested, therefore resulting to be a suitable vector to deliver anticancer agents to tumor cells.
Journal ArticleDOI
Water-Soluble Cationic Aromatic Dendrimers and Their Complexation with DNA
Zinaida B. Shifrina,N. V. Kuchkina,Pavel N. Rutkevich,T. N. Vlasik,Anna D. Sushko,Vladimir A. Izumrudov +5 more
TL;DR: Water-soluble cationic polypyridylphenylene dendrimers (wPPPDs) of different generations and various contents of pyrinium and phenylene moieties were synthesized as discussed by the authors.
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Glycogen and gold nanoparticle bioconjugates : controlled plasmon resonance via glycogen -induced nanoparticle aggregation
TL;DR: The interactions of the gold nanoparticles with glycogen strongly affected the photoluminescence of the glycogenin protein incorporated into its structure and induced a shift of the surface plasmon resonance band towards higher wavelengths on an increase in gold ion concentration.
Journal ArticleDOI
Synthesis of Hyperbranched Polypeptide and PEO Block Copolymer by Consecutive Thiol-Yne Chemistry
Xiao Chang,Chang-Ming Dong +1 more
TL;DR: Compared with a linear counterpart, HPlys-b-PEO gave a higher drug-loading capacity and efficiency for the anticancer drug doxorubicin (DOX) and a slower drug-release rate with an improved burst-release profile, enabling them useful for drug delivery systems.
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A novel hyperbranched polyester made from aconitic acid (B3) and di(ethylene glycol) (A2)
TL;DR: In this article, a new hyperbranched polyester with a high degree of branching was successfully synthesized by A2 + B3 polymerization of di(ethylene glycol) (A2) and aconitic acid (B3) in a 3:2 molecular ratio.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
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Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more