Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
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TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
Citations
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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
TL;DR: Recent advances in the understanding of miRNAs in cancer and in other diseases are described and the challenge of identifying the most efficacious therapeutic candidates is discussed and a perspective on achieving safe and targeted delivery of miRNA therapeutics is provided.
Journal ArticleDOI
Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
Journal ArticleDOI
Thermo- and pH-responsive polymers in drug delivery.
TL;DR: The majority of examples, discussed in this paper, deal with pH-responsive drug delivery system, and Thermo-responsive polymer is also covered to a large extent, as well as double-responsive system.
Journal ArticleDOI
The effect of particle design on cellular internalization pathways
Stephanie E. A. Gratton,Patricia A. Ropp,Patrick D. Pohlhaus,J. Christopher Luft,Victoria J. Madden,Mary E. Napier,Joseph M. DeSimone +6 more
TL;DR: These findings suggest that HeLa cells readily internalize nonspherical particles with dimensions as large as 3 μm by using several different mechanisms of endocytosis, and it was found that rod-like particles enjoy an appreciable advantage when it comes to internalization rates.
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Polymer conjugates as anticancer nanomedicines
TL;DR: There is growing optimism that ever more sophisticated polymer-based vectors will be a signficant addition to the armoury currently used for cancer therapy.
References
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Journal ArticleDOI
Dendrimeric Supramolecular and Supramacromolecular Assemblies
TL;DR: Ciferri et al. as mentioned in this paper presented a Supramolecular Polymers, Ciferri, A., Ed., Marcel Dekker, Inc., New York, 2000, 359-434.
Journal ArticleDOI
Boronated epidermal growth factor as a delivery agent for neutron capture therapy of EGF receptor positive gliomas.
Weil Ian Yang,Rolf F. Barth,Gong Wu,Achintya K. Bandyopadhyaya,B. T. S. Thirumamagal,Werner Tjarks,Peter J. Binns,Kent J. Riley,Hemant Patel,Jeffrey A. Coderre,Michael J. Ciesielski,Robert A. Fenstermaker +11 more
TL;DR: Data show that CED improved the radiobiological effectiveness of BD-EGF and lay the groundwork for future studies using combinations of boron delivery agents for NCT of EGFR(+) gliomas.
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Mechanism of enhancement effect of dendrimer on transdermal drug permeation through polyhydroxyalkanoate matrix.
Zhixiong Wang,Yoshiaki Itoh,Yoshifumi Hosaka,Ichiro Kobayashi,Yoshihisa Nakano,Isamu Maeda,Fusako Umeda,Junji Yamakawa,Mari Nishimine,Tomoyoshi Suenobu,Shunichi Fukuzumi,Masaya Kawase,Kiyohito Yagi +12 more
TL;DR: X-ray analyses were performed to investigate the mechanism of the enhancement effect of a dendrimer on the tamsulosin TDDS, and found that drug crystallization in PHA was promoted, which is very important for exploiting high-performance PHA-based TDDSs.
Journal ArticleDOI
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: Accelerated renal excretion with coinjection of lysine
Hisataka Kobayashi,Noriko Sato,Satomi Kawamoto,Tsuneo Saga,Akira Hiraga,Takayoshi Ishimori,Junji Konishi,Kaori Togashi,Martin W. Brechbiel +8 more
TL;DR: The effect of coinjecting lysine to accelerate renal excretion of a macromolecular MRI‐CA (generation‐4 PAMAM™ dendrimer (G4D‐(1B4M‐Gd)64) was investigated, and the serial signal intensity (SI) change in the blood and organs was evaluated.
Related Papers (5)
Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more