Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
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TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
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Collagen cross linking agents: design and development of a multifunctional cross linker.
TL;DR: A new cross linking reagent based on the first‐generation polyamidoamine dendrimer has been synthesized by reaction of the PAMAM with eight equivalents of p‐nitrophenyl diazopyruvate and showed to undergo Wolff rearrangements upon photolysis in methanol to yield the methyl esters of the ketenes formed from the loss of nitrogen.
Journal ArticleDOI
Synthesis of mesoporous silica/polyglutamic acid peptide dendrimer with dual targeting and its application in dissolving thrombus
Mengjie Huang,Shao-Fei Zhang,Shaoyu Lü,Taomei Qi,Jia Yan,Chunmei Gao,Mingzhu Liu,Tao Li,Yanzheng Ji +8 more
TL;DR: Thrombus-targeting nanocomposites M-MSNs-G3 -RGD/NK were prepared by loading the thrombolytic drug NK via electrostatic interaction, and in vitro and in vivo targeted throm bolytic experiments showed that the nanoparticles exhibited significant thROMbolysis ability.
Journal ArticleDOI
Highly water-soluble, pH sensitive and biocompatible PAMAM 'dendrizyme' to maintain catalytic activity in complex medium.
Longgang Wang,Yanshuai Cui,Shengfu Chen,Shengfu Chen,Guangzhi Wang,Dawei Gao,Yanping Liu,Qiaoyue Luo,Zhiwei Liu,Xuwu Zhang +9 more
TL;DR: The surface functionalization schemes described in this report would represent a versatile method to prepare water-soluble, pH sensitive, biocompatible, and efficient artificial enzymes for biomedical related applications.
Journal ArticleDOI
Study of cationic carbosilane dendrimers as potential activating stimuli in macrophages
Javier Sánchez-Nieves,A. Judith Perisé-Barrios,Paula Ortega,Angel L. Corbí,Ángeles Domínguez-Soto,M. Ángeles Muñoz-Fernández,Rafael Gómez,F. Javier de la Mata +7 more
TL;DR: In this paper, a cationic carbosilane dendrimer with two ammonium groups per branch [GnO3(SiONN)m]2m+ was derived from the 1,3,5-trihydroxybenzene core.
Journal ArticleDOI
Layer-by-layer supramolecular assemblies based on linear and star-shaped poly(glycerol methacrylate)s for doxorubicin delivery.
TL;DR: Hollow microcapsules, composed of pH responsive polyelectrolytes via a layer-by-layer (LBL) adsorption technique, exhibited better cell viability and were used to load an anticancer drug, doxorubicin hydrochloride.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
Related Papers (5)
Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more