Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
Reads0
Chats0
TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
Citations
More filters
Journal ArticleDOI
One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell
TL;DR: A versatile method of one-step conjugation of glycyrrhetinic acid (GA) to reduce cytotoxicity and improve the cultured liver cell -targeting capability of cationic polymers is reported, suggesting that the new GA-PPI dendrimer are a promising candidate gene carrier for targeted liver cancer therapy.
Journal ArticleDOI
Branched Polymer-Drug Conjugates for Multivalent Blockade of Angiotensin II Receptors.
TL;DR: With sufficiently long vitreous half-lives, both synthesized polymer-ARB conjugates have the potential to pave a new path for the therapy of ocular diseases accompanied by retinal neovascularizations.
Journal ArticleDOI
Dendrimers as nonviral vectors in dendritic cell-based immunotherapies against human immunodeficiency virus: steps toward their clinical evaluation
Enrique Vacas-Córdoba,Núria Climent,Francisco Javier de la Mata,Montserrat Plana,Rafael Gómez,Marjorie Pion,Felipe García,María Ángeles Muñoz-Fernández +7 more
TL;DR: This review focuses on the first steps for clinical development of dendrimers to assess their safety and potential use in DC-based immunotherapies against HIV.
Journal ArticleDOI
Synthesis and characterization of dendritic star-shaped zwitterionic polymers as novel anticancer drug delivery carriers
TL;DR: PAMAM-g-PDMAPS polymers, even starting from low-generation PAMAM core (G2), were found to show high loading efficiency for ADR, which demonstrated that dendritic star-shaped zwitterionic polymers P AMAM- g- PDMAPS are attractive candidates as anticancer drug delivery carriers.
Journal ArticleDOI
Supramolecular hybrid assemblies based on gold nanoparticles, amphiphilic cyclodextrin and porphyrins with combined phototherapeutic action
Mariachiara Trapani,Andrea Romeo,Tiziana Parisi,Maria Teresa Sciortino,Salvatore Patanè,Valentina Villari,Antonino Mazzaglia +6 more
TL;DR: These assemblies induce low dark toxicity and a combined photothermal–photodynamic effect upon proper irradiation, showing promising properties as dual-action phototherapeutics.
References
More filters
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
Related Papers (5)
Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more