Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
Reads0
Chats0
TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
Citations
More filters
Journal ArticleDOI
Glycopeptide dendrimers. Part II.
TL;DR: Glycopeptide dendrimers can be used as inhibitors of cell surface protein‐carbohydrate interactions, intervention with bacterial adhesion, for studying of recognition processes, diagnostics, imaging and contrast agents, mimetics, for complexation of different cationts, as site‐specific molecular delivery systems, for therapeutic purposes, as immunodiagnostics and in drug design.
Journal ArticleDOI
Double targeting of tumours with pyrenyl-modified dendrimers encapsulated in an arene-ruthenium metallaprism.
Anaïs Pitto-Barry,Nicolas P. E. Barry,Olivier Zava,Robert Deschenaux,Paul J. Dyson,Bruno Therrien +5 more
TL;DR: The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene-ruthenium building blocks and 5,8-dioxido-1,4-naphthoquinonato (donq) bridges affords the triangular prismatic host-guest compounds.
Journal ArticleDOI
Nitric Oxide-Releasing Quaternary Ammonium-Modified Poly(amidoamine) Dendrimers as Dual Action Antibacterial Agents
TL;DR: Bactericidal activity was found to be dependent on dendrimer generation, QA alkyl chain length, and bacterial Gram class for both systems, with NO release markedly enhancing overall killing.
Journal ArticleDOI
Nanoantibiotics: Future nanotechnologies to combat antibiotic resistance.
Saima Muzammil,Sumreen Hayat,Muhammad Fakhar-e-Alam,Bilal Aslam,Muhammad Hussnain Siddique,Mhammad Atif Nisar,Muhammad Saqalein,Muhammad Atif,Ayesha Sarwar,Anwaar Khurshid,Nasir Amin,Zhiming Wang +11 more
TL;DR: This review provides a detailed view about the role of metal and metal oxide nanoparticles in the treatment of infections in conjunction with antibiotics, their modes of action, and synergism, and the problems of multidrug resistance are addressed to allow the development of a comprehensive, reliable, and rational treatment plan.
Journal ArticleDOI
Nanocarriers for transdermal drug delivery
José Juan Escobar-Chávez,Roberto Díaz-Torres,Isabel Marlen Rodríguez-Cruz,Clara Luisa Domínguez-Delgado,Rafael Sampere Morales,Enrique Ángeles-Anguiano,Luz María Melgoza-Contreras +6 more
TL;DR: In this paper, the authors present the results of a study conducted at the Universidad Nacional Autonoma de Mexico (Unidad de Ensenanza e Investigación, Hospital Regional de Alta Especialidad de Zumpango (HESI) in Mexico.
References
More filters
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
Related Papers (5)
Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more