Journal ArticleDOI
Dendrimer biocompatibility and toxicity.
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TLDR
Preclinical and clinical experience gained during the development of polymeric excipients, biomedical polymers and polymer therapeutics shows that judicious development of dendrimer chemistry for each specific application will ensure development of safe and important materials for biomedical and pharmaceutical use.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2005-12-14. It has received 1083 citations till now.read more
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Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis
TL;DR: Dendrimer-based nanocarriers to deliver insulin-like growth factor 1 (IGF-1) to chondrocytes within joint cartilage and PEGylated PAMAM dendrimers could improve pharmacokinetics and efficacy of disease-modifying osteoarthritis drugs in the clinic are suggested.
Journal ArticleDOI
Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities.
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the response of the immune system to EMTs.
Journal ArticleDOI
Characterization of carbosilane dendrimers as effective carriers of siRNA to HIV-infected lymphocytes.
Nicholas D. Weber,Paula Ortega,Paula Ortega,Maria Clemente,Maria Clemente,Dzmitry Shcharbin,Maria Bryszewska,F. Javier de la Mata,F. Javier de la Mata,Rafael Gómez,Rafael Gómez,M. Ángeles Muñoz-Fernández,M. Ángeles Muñoz-Fernández +12 more
TL;DR: Dendriplexes with +/- charge ratio of 2 were determined to have the highest transfection efficiency while maintaining a low level of toxicity in these systems including hard-to-transfect HIV-infected PBMC and SupT1.
Journal ArticleDOI
Nanoparticulate Systems for Growth Factor Delivery
Sufeng Zhang,Hasan Uludağ +1 more
TL;DR: The therapeutic applications of growth factors delivered by nanoparticulate systems designed for effective intact growth factor delivery are reviewed, especially for bone, skin and nerve regeneration as well as angiogenesis.
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Degradable self-assembling dendrons for gene delivery: experimental and theoretical insights into the barriers to cellular uptake.
Anna Barnard,Paola Posocco,Sabrina Pricl,Marcelo Calderón,Rainer Haag,Mark E. Hwang,Victor W. T. Shum,Daniel W. Pack,David K. Smith +8 more
TL;DR: It is shown, both experimentally and theoretically, that gene delivery can be correlated with the ability of the dendron assemblies to release DNA, and it is shown that taking this kind of multidisciplinary approach can yield a fundamental insight into the way in which dendrons can navigate barriers to cellular uptake.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
A new class of polymers: Starburst-dendritic macromolecules
Donald A. Tomalia,H. Baker,James R Dewald,Michael B. Hall,G. Kallos,Steven J. Martin,J. Roeck,J. Ryder,Patrick B. Smith +8 more
TL;DR: Starburst polymers as mentioned in this paper are a class of topological macromolecules which are derived from classical monomers/oligomers by their extraordinary symmetry, high branching and maximized terminal functionality density.
Journal ArticleDOI
The dawning era of polymer therapeutics
TL;DR: The successful clinical application of polymer–protein conjugates, and promising clinical results arising from trials with polymer–anticancer-drug conjugate, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
Journal ArticleDOI
Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
TL;DR: Starburst dendrimers are three-dimensional, highly ordered oligomeric and polymeric compounds formed by reiterative reaction sequences starting from smaller molecules—“initiator cores” such as ammonia or pentaerythritol.
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Dendrimers in biomedical applications--reflections on the field.
Sonke Svenson,Donald A. Tomalia +1 more