scispace - formally typeset
Journal ArticleDOI

Dendrimers of citric acid and poly (ethylene glycol) as the new drug-delivery agents.

Hassan Namazi, +1 more
- 01 Apr 2005 - 
- Vol. 26, Iss: 10, pp 1175-1183
TLDR
The structure definition and controlled release of the molecules and drugs were carried out using different spectroscopy methods and some of the small size molecule and drugs are trapped with the above-synthesized dendrimers.
About
This article is published in Biomaterials.The article was published on 2005-04-01. It has received 247 citations till now. The article focuses on the topics: Dendrimer & Drug carrier.

read more

Citations
More filters
Journal ArticleDOI

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

TL;DR: This review focuses on several crucial issues related to the role of dendrimers as nanoscaffolding and nanocontainers, crucial principles that might be invoked for improvingdendrimer cytotoxicity properties, understanding dendricer cellular transport mechanisms and the exciting role ofDendriming as high-contrast MRI imaging agents.
Journal ArticleDOI

Dendrimer toxicity: Let's meet the challenge.

TL;DR: In this paper, a review of the approaches available to overcome the cationic toxicity inherent associated with the dendrimers is presented, where two strategies have been utilized; first, designing and synthesis of biocompatible dendrrimers; and second, masking of peripheral charge of dendrigers by surface engineering.
Journal ArticleDOI

Dendrimers as versatile platform in drug delivery applications.

TL;DR: Many commercial small molecule drugs with anticancer, anti-inflammatory, and antimicrobial activity have been successfully associated with dendrimers such as poly(amidoamine) (PAMAM), poly(propylene imine) (PPI or DAB) and poly(etherhydroxylamine), either via physical interactions or through chemical bonding ('prodrug approach').
Journal ArticleDOI

Dendrimer–drug interactions ☆

TL;DR: The application of dendrimer-drug complexation in the enhancement of drug solubility and bioavailability and the use of the complexes as vehicles for the controlled release of drugs and drug targeting is discussed.
References
More filters
Journal ArticleDOI

Encapsulation of guest molecules into a dendritic box.

TL;DR: The synthesis and characterization of dendritic boxes, based on the construction of a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups, is reported here, showing that a dense shell with solid-phase character is formed.
Journal ArticleDOI

Block copolymer micelles as vehicles for drug delivery

TL;DR: In this article, the authors focused on the promising features of block copolymer micelles as drug vehicles mimicking the natural carrier-systems with supramolecular structures (i.e. viruses and lipoproteins).
Journal ArticleDOI

Dendrimers: From Design to Application-A Progress Report.

TL;DR: A unique combination of a clearly defined particle structure and a very highly functionalized surface is offered by the topical dendrimers and an MRI contrast agent based on dendedrimers that facilitate the visualization of bloodstreams is developed.
Journal ArticleDOI

Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering.

TL;DR: The biological activities of these materials can be tailored to meet the requirements of a given tissue engineering application by creating a mixture of various bioactive PEG derivatives prior to photopolymerization.
Journal ArticleDOI

Dendrimers—Branching out from curiosities into new technologies

TL;DR: A review of the theories and concepts surrounding dendrimer syntheses without becoming an exhaustive catalogue of the literature can be found in this paper, where a significant effort is made to examine the numerous applications that are beginning to emerge for these fascinating polymers.
Related Papers (5)