Journal ArticleDOI
Dengue vaccine: hypotheses to understand CYD-TDV-induced protection
Bruno Guy,Nicholas Jackson +1 more
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TLDR
The putative mechanisms behind the observed efficacy of the vaccine against different forms of the disease are discussed, focusing on the interactions between the infecting virus, pre-existing host immunity and vaccine-induced immune responses.Abstract:
Dengue virus (DENV) is a human pathogen with a large impact on public health. Although no vaccine against DENV is currently licensed, a recombinant vaccine - chimeric yellow fever virus-DENV tetravalent dengue vaccine (CYD-TDV) - has shown efficacy against symptomatic dengue disease in two recent Phase III clinical trials. Safety observations were also recently reported for these trials. In this Opinion article, we review the data from recent vaccine clinical trials and discuss the putative mechanisms behind the observed efficacy of the vaccine against different forms of the disease, focusing on the interactions between the infecting virus, pre-existing host immunity and vaccine-induced immune responses.read more
Citations
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Journal ArticleDOI
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
Norbert Pardi,Michael J. Hogan,Rebecca S. Pelc,Hiromi Muramatsu,Hanne Andersen,Christina R. DeMaso,Kimberly A. Dowd,Laura L. Sutherland,Richard M. Scearce,Robert Parks,Wendeline Wagner,Alex Granados,Jack Greenhouse,Michelle Walker,Elinor Willis,Jae-Sung Yu,Charles E. McGee,Gregory D. Sempowski,Barbara L. Mui,Ying K. Tam,Yan Jang Huang,Dana L. Vanlandingham,Veronica M. Holmes,Harikrishnan Balachandran,Sujata Sahu,Michelle A. Lifton,Stephen Higgs,Scott E. Hensley,Thomas D. Madden,Michael J. Hope,Katalin Karikó,Sampa Santra,Barney S. Graham,Mark G. Lewis,Theodore C. Pierson,Barton F. Haynes,Drew Weissman +36 more
TL;DR: It is demonstrated that a single low-dose intradermal immunization with nucleoside-modified mRNA–LNP elicits rapid and durable protective immunity and therefore represents a new and promising vaccine candidate for the global fight against ZIKV.
Journal ArticleDOI
Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy
Saranya Sridhar,Alex Luedtke,Edith Langevin,Ming Zhu,Matthew Bonaparte,Tifany Machabert,Stephen Savarino,Betzana Zambrano,Annick Moureau,Alena Khromava,Zoe Moodie,Ted Westling,Cesar Mascareñas,Carina Frago,Margarita Cortés,Danaya Chansinghakul,Fernando Noriega,Alain Bouckenooghe,Josh Chen,Su-Peing Ng,Peter B. Gilbert,Sanjay Gurunathan,Carlos A. DiazGranados +22 more
TL;DR: CYD‐TDV protected against severe VCD and hospitalization for VCD for 5 years in persons who had exposure to dengue before vaccination, and there was evidence of a higher risk of these outcomes in vaccinated people who had not been exposed to d Dengue.
Journal ArticleDOI
Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Justin M. Richner,Brett W. Jagger,Chao Shan,Camila R. Fontes,Kimberly A. Dowd,Bin Cao,Sunny Himansu,Elizabeth A. Caine,Bruno Tardelli Diniz Nunes,Bruno Tardelli Diniz Nunes,Daniele Barbosa de Almeida Medeiros,Daniele Barbosa de Almeida Medeiros,Antonio E. Muruato,Bryant M. Foreman,Huanle Luo,Tian Wang,Alan D.T. Barrett,Scott C. Weaver,Pedro Fernando da Costa Vasconcelos,Pedro Fernando da Costa Vasconcelos,Shannan L. Rossi,Giuseppe Ciaramella,Indira U. Mysorekar,Theodore C. Pierson,Pei Yong Shi,Michael S. Diamond +25 more
TL;DR: Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise.
Journal ArticleDOI
Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment.
Neil M. Ferguson,Isabel Rodriguez-Barraquer,Ilaria Dorigatti,Luis Mier-y-Teran-Romero,Daniel J Laydon,Derek A. T. Cummings,Derek A. T. Cummings +6 more
TL;DR: It is proposed that this live attenuated vaccine acts like a silent natural infection in priming or boosting host immunity, and a transmission dynamic model incorporating this hypothesis fits recent clinical trial data well and predicts that vaccine effectiveness depends strongly on the age group vaccinated and local transmission intensity.
Journal ArticleDOI
The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study
Stefan Flasche,Mark Jit,Isabel Rodriguez-Barraquer,Laurent Coudeville,Mario Recker,Katia Koelle,George J. Milne,Thomas J. Hladish,T. Alex Perkins,Derek A. T. Cummings,Derek A. T. Cummings,Ilaria Dorigatti,Daniel J Laydon,Guido España,Joel Kelso,Ira M. Longini,José Lourenço,Carl A. B. Pearson,Robert C. Reiner,Luis Mier-y-Teran-Romero,Kirsten S. Vannice,Neil M. Ferguson +21 more
TL;DR: Predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9).
References
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Journal ArticleDOI
The global distribution and burden of dengue
Samir Bhatt,Peter W. Gething,Oliver J. Brady,Jane P. Messina,Andrew Farlow,Catherine L. Moyes,John M. Drake,John M. Drake,John S. Brownstein,Anne G. Hoen,Osman Sankoh,Osman Sankoh,Monica F. Myers,Dylan B. George,Thomas Jaenisch,G. R. William Wint,Cameron P. Simmons,Thomas W. Scott,Thomas W. Scott,Jeremy Farrar,Jeremy Farrar,Simon I. Hay,Simon I. Hay +22 more
TL;DR: These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.
Journal ArticleDOI
Dengue: a continuing global threat
María G. Guzmán,Scott B. Halstead,Harvey Artsob,Philippe Buchy,Jeremy Farrar,Duane J. Gubler,Elizabeth Hunsperger,Axel Kroeger,Harold S. Margolis,Eric Martinez,Michael B. Nathan,José L. Pelegrino,Cameron P. Simmons,Sutee Yoksan,Rosanna W. Peeling,Rosanna W. Peeling +15 more
TL;DR: A global strategy aimed at increasing the capacity for surveillance and outbreak response, changing behaviours and reducing the disease burden using integrated vector management in conjunction with early and accurate diagnosis has been advocated.
Journal ArticleDOI
Research on dengue during World War II.
TL;DR: Dengue research was brought from the field into the laboratory and further progress has been made possible by work on experimental animals instead of on human volunteers, and a great deal more was learned about the basic properties of the dengue viruses.
Journal ArticleDOI
Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease
Hadinegoro,José Luis Arredondo-García,Maria Rosario Capeding,Carmen Deseda,Chotpitayasunondh T,Reynaldo Dietze,Muhammad Ismail Hi,Humberto Reynales,Kriengsak Limkittikul,Doris Maribel Rivera-Medina,Tran Hn,Alain Bouckenooghe,Danaya Chansinghakul,Margarita Cortés,Fanouillere K,Forrat R,Carina Frago,Sophia Gailhardou,Jackson N,Fernando Noriega,Eric Plennevaux,Tram Anh Wartel,Betzana Zambrano,Melanie Saville +23 more
TL;DR: Although the unexplained higher incidence of hospitalization for dengue in year 3 among children younger than 9 years of age needs to be carefully monitored during long-term follow-up, the risk among children 2 to 16 years ofAge was lower in the vaccine group than in the control group.
Journal ArticleDOI
Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial
Maria Rosario Capeding,Ngoc Huu Tran,Sri Rezeki Hadinegoro,Hussain Imam Muhammad Ismail,Tawee Chotpitayasunondh,Mary Noreen Chua,Chan Quang Luong,Kusnandi Rusmil,Dewa Nyoman Wirawan,Revathy Nallusamy,Punnee Pitisuttithum,Usa Thisyakorn,In-Kyu Yoon,Diane van der Vliet,Edith Langevin,Thelma Laot,Yanee Hutagalung,Carina Frago,Mark Boaz,T. Anh Wartel,Nadia Tornieporth,Melanie Saville,Alain Bouckenooghe +22 more
TL;DR: The findings show that dengue vaccine is efficacious when given as three injections at months 0, 6, and 12 to children aged 2-14 years in endemic areas in Asia, and has a good safety profile.
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