Dental disease and risk of coronary heart disease and mortality.
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TLDR
Dental disease is associated with an increased risk of coronary heart disease, particularly in young men, and may be a more general indicator of personal hygiene and possibly health care practices.Abstract:
OBJECTIVE--To investigate a reported association between dental disease and risk of coronary heart disease. SETTING--National sample of American adults who participated in a health examination survey in the early 1970s. DESIGN--Prospective cohort study in which participants underwent a standard dental examination at baseline and were followed up to 1987. Proportional hazards analysis was used to estimate relative risks adjusted for several covariates. MAIN OUTCOME MEASURES--Incidence of mortality or admission to hospital because of coronary heart disease; total mortality. RESULTS--Among all 9760 subjects included in the analysis those with periodontitis had a 25% increased risk of coronary heart disease relative to those with minimal periodontal disease. Poor oral hygiene, determined by the extent of dental debris and calculus, was also associated with an increased incidence of coronary heart disease. In men younger than 50 years at baseline periodontal disease was a stronger risk factor for coronary heart disease; men with periodontitis had a relative risk of 1.72. Both periodontal disease and poor oral hygiene showed stronger associations with total mortality than with coronary heart disease. CONCLUSION--Dental disease is associated with an increased risk of coronary heart disease, particularly in young men. Whether this is a causal association is unclear. Dental health may be a more general indicator of personal hygiene and possibly health care practices.read more
Citations
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WBC count, atherosclerosis and coronary risk factors.
TL;DR: The data suggest that values significantly higher than this could be an important indicator of inflammation derived from cigarette smoking or periodontal disease, and whether an improvement in the WBC count could prevent the occurrence of CHD.
Are periodontal diseases risk factors for certain systemic disorders--what matters to medical practitioners?
TL;DR: periodontal diseases may be risk factors for cardiovascular disease, diabetes mellitus, adverse pregnancy outcomes, and pulmonary infections and dental and medical practitioners should be aware of the clinical implications of these inter-relationships and treat affected patients in collaboration for better oral and general health.
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Nasal vaccination with the 40-kilodalton outer membrane protein of Porphyromonas gingivalis and a nontoxic chimeric enterotoxin adjuvant induces long-term protective immunity with reduced levels of immunoglobulin E antibodies.
Fumiki Momoi,Tomomi Hashizume,Tomoko Kurita-Ochiai,Yoshikazu Yuki,Hiroshi Kiyono,Masafumi Yamamoto +5 more
TL;DR: Nasally administered 40-kDa OMP together with mCTA/LTB should be an effective and safe mucosal vaccine against P. gingivalis infection in humans and may be an important tool for the prevention of chronic periodontitis.
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Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease.
Shaneen J. Leishman,Pauline J. Ford,Hong Lien Do,J. E. Palmer,Nicholas C. K. Heng,Malcolm J. West,Gregory J. Seymour,Gregory J. Seymour,Mary P. Cullinan,Mary P. Cullinan +9 more
TL;DR: In cardiovascular patients, a greater burden of subgingival infection with increased levels of P. gingivalis and T. forsythia is associated with modestly higher anti-hHSP60 levels, which were seen in patients with extensive periodontal pocketing and all four bacterial species.
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Periodontal, metabolic, and cardiovascular disease: Exploring the role of inflammation and mental health.
Hina Makkar,Mark A. Reynolds,Abhishek Wadhawan,Aline Dagdag,Anwar T. Merchant,Teodor T. Postolache +5 more
TL;DR: Future longitudinal studies should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.
References
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Journal ArticleDOI
Association between dental health and acute myocardial infarction.
Kimmo Mattila,M. S. Nieminen,Ville Valtonen,V. P. Rasi,Y. A. Kesäniemi,S. L. Syrjälä,P. S. Jungell,M. Isoluoma,K. Hietaniemi,M. J. Jokinen +9 more
TL;DR: The association between poor dental health and acute myocardial infarction was investigated in two separate case-control studies and remained valid after adjustment for age, social class, smoking, serum lipid concentrations, and the presence of diabetes.
Journal ArticleDOI
Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study.
Pekka Saikku,M. Leinonen,L. Tenkanen,E Linnanmäki,M. R. Ekman,Vesa Manninen,Matti Mänttäri,M H Frick,J K Huttunen +8 more
TL;DR: The results suggest that chronic C. pneumoniae infection may be a significant risk factor for the development of coronary heart disease.
Journal ArticleDOI
Association of prior infection with Chlamydia pneumoniae and angiographically demonstrated coronary artery disease
TL;DR: The results generally support the previously reported association between C pneumoniae infection and coronary heart disease, and caution should be used in interpreting the basis for this association.
Journal Article
The relative importance of selected risk factors for various manifestations of cardiovascular disease among men and women from 35 to 64 years old: 30 years of follow-up in the Framingham Study
TL;DR: Differences were noted in the risk profiles for various manifestations of cardiovascular disease (CVD) that occurred before the age of 65 during the first 30 years of follow-up of the 5070 subjects of the original Framingham cohort, highlighting the need for future studies to distinguish better between those factors that precipitate cardiovascular events and those that relate to the pathogenesis of the underlying atherosclerosis.