Dental disease and risk of coronary heart disease and mortality.
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TLDR
Dental disease is associated with an increased risk of coronary heart disease, particularly in young men, and may be a more general indicator of personal hygiene and possibly health care practices.Abstract:
OBJECTIVE--To investigate a reported association between dental disease and risk of coronary heart disease. SETTING--National sample of American adults who participated in a health examination survey in the early 1970s. DESIGN--Prospective cohort study in which participants underwent a standard dental examination at baseline and were followed up to 1987. Proportional hazards analysis was used to estimate relative risks adjusted for several covariates. MAIN OUTCOME MEASURES--Incidence of mortality or admission to hospital because of coronary heart disease; total mortality. RESULTS--Among all 9760 subjects included in the analysis those with periodontitis had a 25% increased risk of coronary heart disease relative to those with minimal periodontal disease. Poor oral hygiene, determined by the extent of dental debris and calculus, was also associated with an increased incidence of coronary heart disease. In men younger than 50 years at baseline periodontal disease was a stronger risk factor for coronary heart disease; men with periodontitis had a relative risk of 1.72. Both periodontal disease and poor oral hygiene showed stronger associations with total mortality than with coronary heart disease. CONCLUSION--Dental disease is associated with an increased risk of coronary heart disease, particularly in young men. Whether this is a causal association is unclear. Dental health may be a more general indicator of personal hygiene and possibly health care practices.read more
Citations
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Porphyromonas gingivalis Bacteremia Induces Coronary and Aortic Atherosclerosis in Normocholesterolemic and Hypercholesterolemic Pigs
Nadine Brodala,Elizabeth P. Merricks,Dwight A. Bellinger,Damrong Damrongsri,Steven Offenbacher,James C. Beck,Phoebus N. Madianos,Daniela Sotres,Yu-Ling Chang,Gary G. Koch,Timothy C. Nichols +10 more
TL;DR: Recurrent P gingivalis bacteremia induces aortic and coronary lesions consistent with atherosclerosis in normocholesterolemic pigs and increases aorti and coronary atherosclerotic lesions in hypercholesterolesmic pigs.
Journal ArticleDOI
Systemic Inflammation in Cardiovascular and Periodontal Disease: Comparative Study
Ingrid Glurich,Sara G. Grossi,Boris Albini,Alex W. Ho,Rashesh Shah,Mohamed Zeid,Heinz Baumann,Robert J. Genco,Ernesto De Nardin +8 more
TL;DR: The data support the hypothesis that localized persistent infection may influence systemic levels of inflammatory mediators and changes in inflammatory mediator levels potentially impact inflammation-associated atherosclerotic processes.
Journal ArticleDOI
Periodontitis decreases the antiatherogenic potency of high density lipoprotein.
Pirkko J. Pussinen,Matti Jauhiainen,Tiina Vilkuna-Rautiainen,Jouko Sundvall,Marja Vesanen,Kimmo Mattila,Timo Palosuo,Georg Alfthan,Sirkka Asikainen +8 more
TL;DR: It is suggested thatperiodontitis causes similar, but milder, changes in HDL metabolism than those that occur during the acute-phase response and that periodontitis may diminish the antiatherogenic potency of HDL, thus increasing the risk for CHD.
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Microbiota in health and diseases
Kaijian Hou,Zhuo-Xun Wu,Xuan-Yu Chen,Jing-Quan Wang,Dongya Zhang,Chuan Xiao,Dan Zhu,Jagadish B. Koya,Liuya Wei,Jilin Li,Zhe S Chen +10 more
TL;DR: The role of microbiota in health and diseases is highlighted by numerous studies since its discovery as mentioned in this paper , which can lead to dysregulation of bodily functions and diseases including cardiovascular diseases (CVDs), cancers, respiratory diseases, etc.
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Detection of bacterial DNA in atheromatous plaques by quantitative PCR.
TL;DR: It is concluded that DNA from oral infectious agents is commonly found in atheromas from young but especially from elderly subjects, and that the contribution of C. pneumoniae to the inflammation may be minimal.
References
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