Development of polyion complex vesicles (PICsomes) from block copolymers for biomedical applications
Reads0
Chats0
TLDR
In this review article, recent progress on PIC vesicles (PICsomes) is summarized and the unique dynamic nature of PICs is described.Abstract:
Polyion complex (PIC) formation is one of the most powerful techniques for obtaining molecular self-assemblies in aqueous media, and useful for material syntheses particularly in the biomedical field. In this review article, recent progress on PIC vesicles (PICsomes) is summarized. PICsomes are characterized by their simple preparation, semipermeability and environment-sensitivity. Very recently, the methods to control structural uniformity and size of the vesicles have been established, and the potential utility of PICsomes has been expanded by crosslinking their PIC layers. In addition, the unique dynamic nature of PICs is also described.read more
Citations
More filters
Journal ArticleDOI
Polyion complex (PIC) particles: Preparation and biomedical applications
TL;DR: A comprehensive discussion of the factors affecting PIC particle self-assembly and their response to physical and chemical stimuli in solution is described in this paper, where a collection of key examples of polyionic nanoparticles for biomedical applications is discussed to illustrate their behaviour and demonstrate the potential of PIC nanoparticles in medicine.
Journal ArticleDOI
Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment
TL;DR: This review highlights design considerations to develop nanoparticle-based approaches for overcoming physiological hurdles in cancer treatment, as well as emerging research in engineering advanced delivery systems for the treatment of primary, metastatic, and multidrug resistant cancers.
Journal ArticleDOI
Recent Tactics and Advances in the Application of Metal Sulfides as High‐Performance Anode Materials for Rechargeable Sodium‐Ion Batteries
Journal ArticleDOI
Polymeric 3D nano-architectures for transport and delivery of therapeutically relevant biomacromolecules
Gesine Gunkel-Grabole,Severin J. Sigg,Mihai Lomora,Samuel Lörcher,Cornelia G. Palivan,Wolfgang Meier +5 more
TL;DR: Different three-dimensional architectures ranging from dendrimers and hyperbranched molecules to micelles, vesicles and nanoparticles assembled from synthetic polymers and peptides are discussed, highlighting seminal examples from the current literature and pointing out the remaining and upcoming challenges.
Journal ArticleDOI
Self-Assembly of siRNA/PEG- b-Catiomer at Integer Molar Ratio into 100 nm-Sized Vesicular Polyion Complexes (siRNAsomes) for RNAi and Codelivery of Cargo Macromolecules.
Beob Soo Kim,Sayan Chuanoi,Tomoya Suma,Yasutaka Anraku,Kotaro Hayashi,Mitsuru Naito,Hyun Jin Kim,Ick Chan Kwon,Kanjiro Miyata,Akihiro Kishimura,Kazunori Kataoka +10 more
TL;DR: The positively charged and cross-linked siRNAsome facilitated siRNA internalization into cultured cancer cells, eliciting significant gene silencing with negligible cytotoxicity.
References
More filters
Journal ArticleDOI
Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI
Nanoparticle therapeutics: an emerging treatment modality for cancer
TL;DR: The features of nanoparticle therapeutics that distinguish them from previous anticancer therapies are highlighted, and how these features provide the potential for therapeutic effects that are not achievable with other modalities are described.
Journal ArticleDOI
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.