Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes
Hiroko Masuda,Keith A. Baggerly,Ying Wang,Ya Zhang,Ana M. Gonzalez-Angulo,Funda Meric-Bernstam,Vicente Valero,Brian D. Lehmann,Jennifer A. Pietenpol,Gabriel N. Hortobagyi,W. Fraser Symmans,Naoto T. Ueno +11 more
TLDR
The clinical relevancy of the 7-subtype classification of triple-negative breast cancer reported by Lehmann and colleagues is confirmed, and may spur innovative personalized medicine strategies for patients with TNBC.Abstract:
Purpose: The clinical relevancy of the 7-subtype classification of triple-negative breast cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated the clinical relevancy of TNBC heterogeneity by determining pathologic complete response (pCR) rates after neoadjuvant chemotherapy, based on TNBC subtypes. Experimental Design: We revalidated the Lehmann and colleagues experiments using Affymetrix CEL files from public datasets. We applied these methods to 146 patients with TNBC with gene expression microarrays obtained from June 2000 to March 2010 at our institution. Of those, 130 had received standard neoadjuvant chemotherapy and had evaluable pathologic response data. We classified the TNBC samples by subtype and then correlated subtype and pCR status using Fisher exact test and a logistic regression model. We also assessed survival and compared the subtypes with PAM50 intrinsic subtypes and residual cancer burden (RCB) index. Results: TNBC subtype and pCR status were significantly associated ( P = 0.04379). The basal-like 1 (BL1) subtype had the highest pCR rate (52%); basal-like 2 (BL2) and luminal androgen receptor had the lowest (0% and 10%, respectively). TNBC subtype was an independent predictor of pCR status ( P = 0.022) by a likelihood ratio test. The subtypes better predicted pCR status than did the PAM50 intrinsic subtypes (basal-like vs. non basal-like). Conclusions: Classifying TNBC by 7 subtypes predicts high versus low pCR rate. We confirm the clinical relevancy of the 7 subtypes of TNBC. We need to prospectively validate whether the pCR rate differences translate into long-term outcome differences. The 7-subtype classification may spur innovative personalized medicine strategies for patients with TNBC. Clin Cancer Res; 19(19); 5533–40. ©2013 AACR .read more
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Journal ArticleDOI
Androgen Receptor in Breast Cancer: From Bench to Bedside.
TL;DR: The roles of AR in different BC subtypes and AR-targeting therapies based on preclinical and clinical studies are summarized and the possible efficacy of a combination therapy via exploiting the AR-related mechanisms and the research on therapeutic resistance is highlighted.
Journal ArticleDOI
Differential expression and clinical significance of epithelial-mesenchymal transition markers among different histological types of triple-negative breast cancer.
TL;DR: EMT may play an important role in TNBC, especially in MPC and SpCC, and the results of this study may facilitate the future development of targeted therapies based on alterations in the EMT and stem cell markers.
Journal ArticleDOI
Tumor characteristics and outcome by androgen receptor expression in triple-negative breast cancer patients treated with neo-adjuvant chemotherapy
Lynn Jongen,Giuseppe Floris,Hans Wildiers,Frank Claessens,Francois Richard,Annouschka Laenen,Christine Desmedt,Jan Ardui,Kevin Punie,Ann Smeets,Patrick Berteloot,Ignace Vergote,Patrick Neven +12 more
TL;DR: Low and high AR-expression on CNB of TNBC were correlated with age and menopausal status but qualitative AR was not predictive for pCR; the MCA suggested that body mass index (BMI) affects the predictive role of AR-low and -high for pCR differently.
Journal ArticleDOI
Breast Cancer and African Ancestry: Lessons Learned at the 10-Year Anniversary of the Ghana-Michigan Research Partnership and International Breast Registry
Evelyn Jiagge,Joseph K. Oppong,Jessica Bensenhaver,Francis Aitpillah,Kofi Gyan,Ishmael Kyei,Ernest Osei-Bonsu,Ernest Adjei,Michael Ohene-Yeboah,Kathy A. Toy,Karen Eubanks Jackson,Marian Akpaloo,Dorcas Acheampong,Beatrice Antwi,Faustina Obeng Agyeman,Zainab Alhassan,Linda Ahenkorah Fondjo,Osei Owusu-Afriyie,Robert Newman Brewer,Amma Gyamfuah,Barbara Salem,Timothy R.B. Johnson,Max S. Wicha,Sofia D. Merajver,Celina G. Kleer,Judy C. Pang,Emmanuel Amankwaa-Frempong,Azadeh Stark,Francis A. Abantanga,Lisa A. Newman,Baffour Awuah +30 more
TL;DR: The history and results of the International Breast Registry are reviewed, at its 10-year anniversary, to include African American patients throughout the United States and additional sites in Ghana and Ethiopia.
Book ChapterDOI
Targeting CSC in a Most Aggressive Subtype of Breast Cancer TNBC.
Bin Bao,Ananda S. Prasad +1 more
TL;DR: Targeting rare subpopulations of CSC/TIC cells might be one of the key contributors to the aggressive phenotypes of TNBC such as drug treatment resistance, metastasis, and tumor recurrence.
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