Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes
Hiroko Masuda,Keith A. Baggerly,Ying Wang,Ya Zhang,Ana M. Gonzalez-Angulo,Funda Meric-Bernstam,Vicente Valero,Brian D. Lehmann,Jennifer A. Pietenpol,Gabriel N. Hortobagyi,W. Fraser Symmans,Naoto T. Ueno +11 more
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TLDR
The clinical relevancy of the 7-subtype classification of triple-negative breast cancer reported by Lehmann and colleagues is confirmed, and may spur innovative personalized medicine strategies for patients with TNBC.Abstract:
Purpose: The clinical relevancy of the 7-subtype classification of triple-negative breast cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated the clinical relevancy of TNBC heterogeneity by determining pathologic complete response (pCR) rates after neoadjuvant chemotherapy, based on TNBC subtypes. Experimental Design: We revalidated the Lehmann and colleagues experiments using Affymetrix CEL files from public datasets. We applied these methods to 146 patients with TNBC with gene expression microarrays obtained from June 2000 to March 2010 at our institution. Of those, 130 had received standard neoadjuvant chemotherapy and had evaluable pathologic response data. We classified the TNBC samples by subtype and then correlated subtype and pCR status using Fisher exact test and a logistic regression model. We also assessed survival and compared the subtypes with PAM50 intrinsic subtypes and residual cancer burden (RCB) index. Results: TNBC subtype and pCR status were significantly associated ( P = 0.04379). The basal-like 1 (BL1) subtype had the highest pCR rate (52%); basal-like 2 (BL2) and luminal androgen receptor had the lowest (0% and 10%, respectively). TNBC subtype was an independent predictor of pCR status ( P = 0.022) by a likelihood ratio test. The subtypes better predicted pCR status than did the PAM50 intrinsic subtypes (basal-like vs. non basal-like). Conclusions: Classifying TNBC by 7 subtypes predicts high versus low pCR rate. We confirm the clinical relevancy of the 7 subtypes of TNBC. We need to prospectively validate whether the pCR rate differences translate into long-term outcome differences. The 7-subtype classification may spur innovative personalized medicine strategies for patients with TNBC. Clin Cancer Res; 19(19); 5533–40. ©2013 AACR .read more
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Pathological Response in a Triple-Negative Breast Cancer Cohort Treated with Neoadjuvant Carboplatin and Docetaxel According to Lehmann's Refined Classification
Isabel Echavarria,Sara López-Tarruella,Antoni Picornell,José A. García-Sáenz,Yolanda Jerez,Katherine A. Hoadley,Henry L. Gomez,Fernando Salvador Moreno,María del Monte-Millán,Ivan Marquez-Rodas,Enrique Alvarez,Rocío Ramos-Medina,Javier Gayarre,Tatiana Massarrah,Inmaculada Ocaña,Maria Cebollero,Hugo Fuentes,Agustí Barnadas,Ana Isabel Ballesteros,Uriel Bohn,Charles M. Perou,Miguel Martin +21 more
TL;DR: Evaluating the performance of the TNBCtype-4 classifier in a cohort of patients with TNBC treated with neoadjuvant carboplatin and docetaxel for six cycles found it associated with significantly different pCR rates for the different subtypes.
Journal ArticleDOI
Racial Differences in the Use and Outcome of Neoadjuvant Chemotherapy for Breast Cancer: Results From the National Cancer Data Base
Brigid K. Killelea,Vicky Q. Yang,Shi-Yi Wang,Brandon Hayse,Sarah S. Mougalian,Nina R. Horowitz,Anees B. Chagpar,Lajos Pusztai,Donald R. Lannin +8 more
TL;DR: Black women have a lower likelihood of pCR for triple-negative and HER2-positive breast cancer, and neoadjuvant chemotherapy is given more frequently to black, Hispanic, and Asian women than to white women.
Journal ArticleDOI
Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options.
Pierluigi Gasparini,Matteo Fassan,Luciano Cascione,Gulnur Guler,Serdar Balci,Cigdem Irkkan,Carolyn Paisie,Francesca Lovat,Carl Morrison,Jianying Zhang,Aldo Scarpa,Carlo M. Croce,Charles L. Shapiro,Kay Huebner +13 more
TL;DR: The findings confirm the prognostic impact of androgen receptor expression in non-basal triple negative breast cancers, and suggest targeting of new androgens receptor-related molecular pathways in patients with these cancers.
Journal ArticleDOI
Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer
Roberto A. Leon-Ferre,Mei Yin C. Polley,Heshan Liu,Judith A. Gilbert,Victoria Cafourek,David W. Hillman,Ahmed Elkhanany,Margaret Akinhanmi,Jenna Lilyquist,Abigail Thomas,Vivian Negron,Judy C. Boughey,Minetta C. Liu,James N. Ingle,Krishna R. Kalari,Fergus J. Couch,Daniel W. Visscher,Matthew P. Goetz +17 more
TL;DR: In early-stage TNBC, nodal involvement, TILs, and receipt of adjuvant chemotherapy were independently associated with IDFS and OS and remained prognostic and the risk of recurrence or death was substantial, even for T1N0 disease.
Journal ArticleDOI
Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer
Yuka Asano,Shinichiro Kashiwagi,Wataru Goto,Sayaka Tanaka,Tamami Morisaki,Tsutomu Takashima,Satoru Noda,Naoyoshi Onoda,Masahiko Ohsawa,Kosei Hirakawa,Masaichi Ohira +10 more
TL;DR: AR expression may be useful as a subclassification marker for prognosis in TNBC and in patients with disease relapse, AR positivity was significantly correlated with better prognosis.
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