Direct Ubiquitination of Pattern Recognition Receptor FLS2 Attenuates Plant Innate Immunity
Dongping Lu,Wenwei Lin,Wenwei Lin,Xiquan Gao,Shujing Wu,Cheng Cheng,Julian Avila,Antje Heese,Timothy P. Devarenne,Ping He,Libo Shan +10 more
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TLDR
This study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 ligases for attenuation of immune signaling.Abstract:
Innate immune responses are triggered by the activation of pattern-recognition receptors (PRRs). The Arabidopsis PRR FLAGELLIN-SENSING 2 (FLS2) senses bacterial flagellin and initiates immune signaling through association with BAK1. The molecular mechanisms underlying the attenuation of FLS2 activation are largely unknown. We report that flagellin induces recruitment of two closely related U-box E3 ubiquitin ligases, PUB12 and PUB13, to FLS2 receptor complex in Arabidopsis. BAK1 phosphorylates PUB12 and PUB13 and is required for FLS2-PUB12/13 association. PUB12 and PUB13 polyubiquitinate FLS2 and promote flagellin-induced FLS2 degradation, and the pub12 and pub13 mutants displayed elevated immune responses to flagellin treatment. Our study has revealed a unique regulatory circuit of direct ubiquitination and turnover of FLS2 by BAK1-mediated phosphorylation and recruitment of specific E3 ligases for attenuation of immune signaling.read more
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Regulation of pattern recognition receptor signalling in plants.
Daniel Couto,Cyril Zipfel +1 more
TL;DR: The mechanisms that fine-tune immune signalling to maintain immune homeostasis are described and how the innate ability of plant cells to monitor the integrity of key immune components can lead to autoimmune phenotypes following genetic or pathogen-induced perturbations of these components are discussed.
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Alberto P. Macho,Cyril Zipfel +1 more
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Plant pattern recognition receptor complexes at the plasma membrane.
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The Magnaporthe oryzae Effector AvrPiz-t Targets the RING E3 Ubiquitin Ligase APIP6 to Suppress Pathogen-Associated Molecular Pattern–Triggered Immunity in Rice
Chan Ho Park,Songbiao Chen,Gautam Shirsekar,Bo Zhou,Chang Hyun Khang,Pattavipha Songkumarn,Ahmed J. Afzal,Yuese Ning,Ruyi Wang,Maria Bellizzi,Barbara Valent,Guo-Liang Wang +11 more
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