Journal ArticleDOI
Diverse lncRNA mechanisms in brain development and disease
TLDR
Circular RNAs are covalently closed single-stranded RNAs that can control neuronal function by acting as microRNA sponges and additional mechanisms to shape the pool of microRNAs and translation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 2020-12-01. It has received 31 citations till now.read more
Citations
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Long noncoding RNAs: Potential therapeutic targets in cardiocerebrovascular diseases
TL;DR: The roles, mechanisms, and clinical value of lncRNAs in cardiocerebrovascular diseases are discussed, providing a new perspective for the diagnosis and treatment of the diseases.
Journal ArticleDOI
Expression Profiles of Long Non-coding RNA and Messenger RNA in Human Traumatic Brain Injury
TL;DR: Investigation of whole blood in patients with TBI and healthy controls found that TBI caused severe immune abnormality reflected on Th1, Th2, and Th17 cell differentiation deficiency, providing novel insight for lncRNAs in human TBI.
Journal ArticleDOI
The potential roles of exosomal noncoding RNAs in osteosarcoma.
TL;DR: The existing literature on the roles of exosomal noncoding RNAs in OS progression and their potential clinical applications as novel biomarkers and therapeutics are reviewed.
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Emerging Potential of Exosomal Non-coding RNA in Parkinson’s Disease: A Review
TL;DR: The diverse characteristics of ncRNAs exosomes are highlighted, which may aid researchers in characterizing future exosome-based biomarkers for early PD diagnosis and tailored PD medicines.
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Long non-coding RNA: An underlying bridge linking neuroinflammation and central nervous system diseases.
TL;DR: In this paper, the potential roles of long non-coding RNAs in modulating neuroinflammation based on current evidence in various CNS diseases are reviewed in order to provide novel explanations for the initiation and progression of CNS diseases and help to establish therapeutic strategies targeting neuro inflammation.
References
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Journal ArticleDOI
Circular RNAs are a large class of animal RNAs with regulatory potency
Sebastian Memczak,Marvin Jens,Antigoni Elefsinioti,Francesca Torti,Janna Krueger,Agnieszka Rybak,Luisa Maier,Sebastian D. Mackowiak,Lea H. Gregersen,Mathias Munschauer,Alexander Loewer,Ulrike Ziebold,Markus Landthaler,Christine Kocks,Ferdinand le Noble,Nikolaus Rajewsky +15 more
TL;DR: It is found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
10 Years of GWAS Discovery: Biology, Function, and Translation
Peter M. Visscher,Naomi R. Wray,Qian Zhang,Pamela Sklar,Mark I. McCarthy,Matthew A. Brown,Jian Yang +6 more
TL;DR: The remarkable range of discoveriesGWASs has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics are reviewed.
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The biogenesis, biology and characterization of circular RNAs.
Lasse Sommer Kristensen,Maria S. Andersen,Lotte V. W. Stagsted,Karoline K. Ebbesen,Thomas B. Hansen,Jørgen Kjems +5 more
TL;DR: Advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
Journal ArticleDOI
Functional Classification and Experimental Dissection of Long Noncoding RNAs
Florian Kopp,Joshua T. Mendell +1 more
TL;DR: This review categorizes lncRNA loci into those that regulate gene expression in cis versus those that perform functions in trans and proposes an experimental approach to dissect lncRNAs activity based on these classifications.