Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
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TLDR
This review considers this review as a selective compilation of approaches and methodologies, and argues how, taken together, they could bring drug repurposing to the next level.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2019-04-01 and is currently open access. It has received 133 citations till now. The article focuses on the topics: Repurposing & Drug development.read more
Citations
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Overcoming cancer therapeutic bottleneck by drug repurposing
TL;DR: This review presents various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono- or drug combination therapy.
Journal ArticleDOI
Drug repurposing for breast cancer therapy: Old weapon for new battle.
TL;DR: A comprehensive overview of the current scenario of drug repurposing for the breast cancer treatment is described and it is suggested that serendipity plays a major role in the drug development.
Journal Article
Immobilized platelets support human colon carcinoma cell tethering, rolling and firm adhesion under dynamic flow conditions
TL;DR: Analysis of the ability of 3 human colon carcinoma cell lines to bind to surface-anchored platelets under flow and to identify the receptors involved in these processes suggests that platelets primarily recruit LS174T cells through a 2-step, sequential process of adhesive interactions that is distinct from that elaborated for neutrophils.
References
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TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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The blockade of immune checkpoints in cancer immunotherapy
TL;DR: Preliminary clinical findings with blockers of additional immune-checkpoint proteins, such as programmed cell death protein 1 (PD1), indicate broad and diverse opportunities to enhance antitumour immunity with the potential to produce durable clinical responses.
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Cancer Genome Landscapes
Bert Vogelstein,Nickolas Papadopoulos,Victor E. Velculescu,Shibin Zhou,Luis A. Diaz,Kenneth W. Kinzler +5 more
TL;DR: This work has revealed the genomic landscapes of common forms of human cancer, which consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of "hills" (Genes altered infrequently).
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