Journal ArticleDOI
Eating microRNAs: pharmacological opportunities for cross-kingdom regulation and implications in host gene and gut microbiota modulation.
Lorena Del Pozo-Acebo,María-Carmen López de Las Hazas,Abelardo Margolles,Abelardo Margolles,Alberto Dávalos,Almudena García-Ruiz,Almudena García-Ruiz +6 more
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TLDR
In this article, the authors give an overview of recent discoveries concerning dietary miRNAs, possible ways of enhancing their resistance to food processing and gut conditions, their transport in extracellular vesicles (animal- and plant-origin) and possible biological effects on recipient cells after ingestion.Abstract:
Cross-kingdom communication via non-coding RNAs is a recent discovery. Exogenous microRNAs (exog-miRNAs) mainly enter the host via the diet. Generally considered unstable in the gastrointestinal tract, some exogenous RNAs may resist these conditions, especially if transported in extracellular vesicles. They could then reach the intestines and more probably exert a regulatory effect. We give an overview of recent discoveries concerning dietary miRNAs, possible ways of enhancing their resistance to food processing and gut conditions, their transport in extracellular vesicles (animal- and plant-origin) and possible biological effects on recipient cells after ingestion. We critically focus on what we believe are the most relevant data for future pharmacological development of dietary miRNAs as therapeutic agents. Finally, we discuss the miRNA-mediated cross-kingdom regulation between diet, host and the gut microbiota. We conclude that, despite many obstacles and challenges, extracellular miRNAs are serious candidates to be targeted pharmacologically for development of new therapeutic agents.read more
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Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression.
María-Carmen López de Las Hazas,Lorena Del Pozo-Acebo,Maria Hansen,Judit Gil-Zamorano,Diana C. Mantilla-Escalante,Diego Gómez-Coronado,Francisco R. Marín,Almudena García-Ruiz,Jan T. Rasmussen,Alberto Dávalos +9 more
TL;DR: In this paper, Bovine-milk extracellular vesicles (EVs) are used to protect miRNAs from degradation and facilitate cellular uptake, but no biological effect has been identified.
Journal ArticleDOI
Lab-to-Field Transition of RNA Spray Applications - How Far Are We?
Aline Pereira Rank,Aline Koch +1 more
TL;DR: In this paper, the authors review the latest advances that could pave the way for a quick lab-to-field transition for RNA sprays, which, as safe, selective, broadly applicable, and cost-effective biopesticides, represent an innovation in sustainable crop production.
Journal ArticleDOI
The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment
Zeyue Zhang,Yang Yu,Guanxiong Zhu,Liting Zeng,Shaofen Xu,Haoyu Cheng,Zhaoguang Ouyang,Jianwei Chen,Janak L. Pathak,Lihong Wu,Lina Yu +10 more
TL;DR: This review summarizes the recent advances in PELNs-related research that are related to the treatment of periodontitis and regeneration ofperiodontitis-destructed tissues and the underlying mechanisms.
Journal ArticleDOI
miRNA-Based Potential Biomarkers and New Molecular Insights in Ulcerative Colitis.
TL;DR: In this article, a review of miRNA for diagnosis, monitoring and prognosis of Ulcerative Colitis (UC) is presented, highlighting the close relationship between miRNA and UC and proposing that the field has value for developing potential biomarkers as well as therapeutic targets for UC.
Journal ArticleDOI
Drug Loading and Functional Efficacy of Cow, Buffalo, and Goat Milk-Derived Exosomes: A Comparative Study.
Farhan Jalees Ahmed,Mounipriya Tamma,Umamaheswari Pathigadapa,Pallu Reddanna,Vengala Rao Yenuganti +4 more
TL;DR: The ability of doxorubicin-encapsulated goat milk exosomes to induce apoptosis in HepG2 and HCT-116 cells was higher than that of cow and buffalo milkExosomes and free doxorbicin, and these observations are important in light of the emerging importance of milk-derived exosome as drug carriers to treat cancers.
References
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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
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In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Raimunda do Socorro da Silva Azevedo,Jorge Rodrigues de Sousa,Marialva Tereza Ferreira de Araújo,Arnaldo Jorge Martins Filho,Bianca Nascimento de Alcantara,Fernanda Montenegro de Carvalho Araújo,Maria G. L. Queiroz,Ana Cecília Ribeiro Cruz,Beatriz H. Baldez Vasconcelos,Jannifer Oliveira Chiang,Lívia Carício Martins,Livia Medeiros Neves Casseb,Eliana Vieira Pinto da Silva,Valéria Lima Carvalho,Barbara Cristina Baldez Vasconcelos,Sueli Rodrigues,Consuelo Silva de Oliveira,Juarez Antônio Simões Quaresma,Pedro Fernando da Costa Vasconcelos +18 more
TL;DR: The in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases were investigated and changes found were mainly calcification, necrosis, neuronophagy, gliosis, microglial nodules, and inflammatory infiltration of mononuclear cells.
Journal ArticleDOI
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
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The MicroRNA Spectrum in 12 Body Fluids
Jessica A. Weber,David Baxter,Shile Zhang,David Huang,Kuo-How Huang,Ming-Jen Lee,David J. Galas,David J. Galas,Kai Wang +8 more
TL;DR: The changes in miRNA spectra observed in the urine samples from patients with different urothelial conditions demonstrates the potential for using concentrations of specific miRNAs in body fluids as biomarkers for detecting and monitoring various physiopathological conditions.
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Treatment of HCV Infection by Targeting MicroRNA
Harry L.A. Janssen,Hendrik W. Reesink,Eric Lawitz,Stefan Zeuzem,Maribel Rodriguez-Torres,Keyur Patel,Adriaan J. van der Meer,Amy K. Patick,Alice Chen,Yi Zhou,Robert Persson,Barney D King,Sakari Kauppinen,Arthur A. Levin,Michael R. Hodges +14 more
TL;DR: The use of miravirsen in patients with chronic HCV genotype 1 infection showed prolonged dose-dependent reductions in HCV RNA levels without evidence of viral resistance.