Effectiveness and safety of oral HIV preexposure prophylaxis for all populations.
Virginia A. Fonner,Sarah L Dalglish,Caitlin E. Kennedy,Rachel Baggaley,Kevin R. O'Reilly,Florence Koechlin,Michelle Rodolph,Ioannis Hodges-Mameletzis,Robert M. Grant,Robert M. Grant,Robert M. Grant +10 more
TLDR
Across populations and PrEP regimens, PrEP significantly reduced the risk of HIV acquisition compared with placebo, and there is no evidence of behavioral risk compensation.Abstract:
Objective:
Preexposure prophylaxis (PrEP) offers a promising new approach to HIV prevention. This systematic review and meta-analysis evaluated the evidence for use of oral PrEP containing tenofovir disoproxil fumarate as an additional HIV prevention strategy in populations at substantial risk for HIV based on HIV acquisition, adverse events, drug resistance, sexual behavior, and reproductive health outcomes.read more
Citations
More filters
Journal ArticleDOI
Chemical recycling to monomer for an ideal, circular polymer economy
TL;DR: In this paper, the authors present a vision for realizing a circular polymer economy based on Chemical Recycling to Monomer (CRM) and examine the energy efficiency of polymerization and other challenges in developing practical and scalable CRM processes.
Journal ArticleDOI
Sexually transmitted infections: challenges ahead
Magnus Unemo,Catriona S. Bradshaw,Jane S Hocking,Henry J. C. de Vries,Suzanna C. Francis,David Mabey,Jeanne M. Marrazzo,Gerard J.B. Sonder,Jane R. Schwebke,Elske Hoornenborg,Rosanna W. Peeling,Susan S. Philip,Nicola Low,Christopher K Fairley +13 more
TL;DR: Overall, this Commission aims to enhance the understanding of some of the key challenges facing the field of STI treatment and control, and outlines new approaches to improve the clinical management of STIs and public health.
Journal ArticleDOI
Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis
Michael W Traeger,Michael W Traeger,Sophia E Schroeder,Sophia E Schroeder,Edwina J. Wright,Margaret Hellard,Margaret Hellard,Vincent J Cornelisse,Joseph Doyle,Joseph Doyle,Mark Stoove,Mark Stoove +11 more
TL;DR: Most studies showed evidence of an increase in condomless sex among PrEP users, and the association of PrEP use with STI diagnoses was stronger in later studies, highlighting the importance of efforts to minimize STIs among Pr EP users and their sexual partners.
Journal ArticleDOI
Mental health and HIV/AIDS: The need for an integrated response
Robert H. Remien,Michael J. Stirratt,Nadia Nguyen,Reuben N. Robbins,Andrea Norcini Pala,Claude A. Mellins +5 more
TL;DR: In this paper, the authors address the significant mental health and substance use problems among people living with HIV (PLWH) and people vulnerable to acquiring HIV (PVC) and highlight the need to prioritize mental health treatment with appropriate resources to address the current mental health screening and treatment gaps.
Journal ArticleDOI
PrEP Awareness, Familiarity, Comfort, and Prescribing Experience among US Primary Care Providers and HIV Specialists
Andrew E. Petroll,Jennifer L. Walsh,Jill Owczarzak,Timothy L. McAuliffe,Laura M. Bogart,Jeffrey A. Kelly +5 more
TL;DR: Efforts to increase PrEP uptake will require interventions to increase the knowledge, comfort, and skills of providers to prescribe PrEP.
References
More filters
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal ArticleDOI
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.
Journal ArticleDOI
Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
TL;DR: Oral FTC-TDF provided protection against the acquisition of HIV infection among the subjects and Detectable blood levels strongly correlated with the prophylactic effect.
Journal ArticleDOI
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Jared M. Baeten,Deborah Donnell,Deborah Donnell,Patrick Ndase,Nelly Mugo,Nelly Mugo,James D. Campbell,Jonathan Wangisi,Jordan W. Tappero,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,Allan R. Ronald,Elioda Tumwesigye,Edwin Were,Kenneth H. Fife,James Kiarie,James Kiarie,Carey Farquhar,Grace John-Stewart,Aloysious Kakia,Josephine Odoyo,Akasiima Mucunguzi,Edith Nakku-Joloba,Rogers Twesigye,Kenneth Ngure,Cosmas Apaka,Harrison Tamooh,Fridah Gabona,Andrew Mujugira,Dana Panteleeff,Katherine K. Thomas,Lara Kidoguchi,Meighan Krows,Jennifer Revall,Susan Morrison,Harald S. Haugen,Mira Emmanuel-Ogier,Lisa Ondrejcek,Robert W. Coombs,Lisa M. Frenkel,Lisa M. Frenkel,Craig W. Hendrix,Namandjé N. Bumpus,David R. Bangsberg,Jessica E. Haberer,Wendy S. Stevens,Jairam R. Lingappa,Connie Celum +49 more
TL;DR: Oral TDF and TDF-FTC both protect against HIV-1 infection in heterosexual men and women, and both study medications significantly reduced the HIV- 1 incidence among both men andWomen.
Related Papers (5)
Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial.
Sheena McCormack,David Dunn,Monica Desai,David Dolling,Mitzy Gafos,Richard Gilson,Richard Gilson,Ann Sullivan,Amanda Clarke,Iain Reeves,Gabriel Schembri,Nicola Mackie,Christine Bowman,Charles J.N. Lacey,Vanessa Apea,Michael Brady,Julie Fox,Stephen Taylor,Simone Antonucci,Saye Khoo,James F. Rooney,Anthony Nardone,Martin Fisher,Alan McOwan,Andrew N. Phillips,Anne M Johnson,Brian Gazzard,ON Gill +27 more
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Jared M. Baeten,Deborah Donnell,Deborah Donnell,Patrick Ndase,Nelly Mugo,Nelly Mugo,James D. Campbell,Jonathan Wangisi,Jordan W. Tappero,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,Allan R. Ronald,Elioda Tumwesigye,Edwin Were,Kenneth H. Fife,James Kiarie,James Kiarie,Carey Farquhar,Grace John-Stewart,Aloysious Kakia,Josephine Odoyo,Akasiima Mucunguzi,Edith Nakku-Joloba,Rogers Twesigye,Kenneth Ngure,Cosmas Apaka,Harrison Tamooh,Fridah Gabona,Andrew Mujugira,Dana Panteleeff,Katherine K. Thomas,Lara Kidoguchi,Meighan Krows,Jennifer Revall,Susan Morrison,Harald S. Haugen,Mira Emmanuel-Ogier,Lisa Ondrejcek,Robert W. Coombs,Lisa M. Frenkel,Lisa M. Frenkel,Craig W. Hendrix,Namandjé N. Bumpus,David R. Bangsberg,Jessica E. Haberer,Wendy S. Stevens,Jairam R. Lingappa,Connie Celum +49 more
On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection
Abstr Act,C. Capitant,Bruno Spire,Gilles Pialoux,Laurent Cotte,Isabelle Charreau,Cécile Tremblay,Eric Cua,Armelle Pasquet,François Raffi,Claire Pintado,Christian Chidiac,Julie Chas,P. Charbonneau,Constance Delaugerre,Marie Suzan-Monti,B. Loze,Gilles Peytavin,A Cheret,Julie Timsit,Gabriel Girard,Nicolas Lorente,Marie Préau,David Thompson,W. Rozenbaum,Véronique Doré,L. Marchand,C. Simon,N. Etien,Laurence Meyer +29 more
Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study
Robert M. Grant,Robert M. Grant,Robert M. Grant,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,K. Rivet Amico,Megha Mehrotra,Sybil G. Hosek,Carlos Mosquera,Martin Casapia,Orlando Montoya,Susan Buchbinder,Valdilea G. Veloso,Kenneth H. Mayer,Suwat Chariyalertsak,Linda-Gail Bekker,Esper G. Kallas,Mauro Schechter,Juan V. Guanira,Lane R. Bushman,David N. Burns,James F. Rooney,David V. Glidden +23 more