Journal ArticleDOI
Effects of TiO2 nanotubes with different diameters on gene expression and osseointegration of implants in minipigs.
TLDR
TiO(2) nanotubes can modulate bone formation events at the bone-implant interface as to reach favorable molecular response and osseointegration and the diameters of nanot tubes can be precisely controlled in order to obtain better bone formation.About:
This article is published in Biomaterials.The article was published on 2011-10-01. It has received 279 citations till now. The article focuses on the topics: Osseointegration & Implant.read more
Citations
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Journal ArticleDOI
PEEK with Reinforced Materials and Modifications for Dental Implant Applications.
Fitria Rahmitasari,Yuichi Ishida,Kosuke Kurahashi,Takashi Matsuda,Megumi Watanabe,Tetsuo Ichikawa +5 more
TL;DR: The current research on PEEK applications in dental implants, especially for the improvement of PEEK surface and body modifications, is summarized.
Journal ArticleDOI
The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells.
TL;DR: The different activation mechanisms of micro- and nano-structures led to the synergistic stimulatory effect on integrin activation and osteogenesis, in which not only the direct contact of cells on micro/nano structure played an important role, but also other surface characteristics such as protein adsorption might contribute to the bioactive effect.
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Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface.
Patricia Neacsu,Anca Mazare,Anisoara Cimpean,Jung Park,Marieta Costache,Patrik Schmuki,Ioana Demetrescu +6 more
TL;DR: In vitro tests showed that TiO2 nanotubes exhibited significantly decreased inflammatory activity of macrophages with respect to cytokine and chemokine gene expression/protein secretion, induction of foreign body giant cells (FBGCs) and nitric oxide (NO) release thereby mitigating the inflammatory response induced by LPS as compared to flat Ti surface.
Journal ArticleDOI
Anodized 3D-printed titanium implants with dual micro- and nano-scale topography promote interaction with human osteoblasts and osteocyte-like cells.
Karan Gulati,Matthew Prideaux,Masakazu Kogawa,Luis Lima-Marques,Gerald J. Atkins,David M. Findlay,Dusan Losic +6 more
TL;DR: Bone implants based on 3D–printed titanium alloy (Ti6Al4V), with a unique dual topography composed of micron‐sized spherical particles and vertically aligned titania nanotubes are presented, suitable for addressing many orthopaedic challenges, including implant rejection, poor osseointegration, inflammation, drug delivery and bone healing.
Journal ArticleDOI
Osteogenesis potential of different titania nanotubes in oxidative stress microenvironment.
Yonglin Yu,Xinkun Shen,Zhong Luo,Yan Hu,Menghuan Li,Pingping Ma,Qichun Ran,Liangliang Dai,Ye He,Kaiyong Cai +9 more
TL;DR: It was found that Wnt signals played an important role in promoting osteogenic differentiation of osteoblasts under oxidative condition, and oxidative stress resistance of large nanotubes was closely related to the high expression of integrin α5β1.
References
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Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Kazuhisa Nakashima,Xin Zhou,Gary R. Kunkel,Zhaoping Zhang,Jian Min Deng,Richard R. Behringer,Benoit de Crombrugghe +6 more
TL;DR: It is proposed that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells, because Osx null preostEoblasts express typical chondrocyte marker genes, and Osx acts downstream of Runx 2/C bfa1.
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Titanium oxide nanotube arrays prepared by anodic oxidation
Dawei Gong,Craig A. Grimes,Oomman K. Varghese,Wenchong Hu,R. S. Singh,Zhi Chen,Elizabeth C. Dickey +6 more
TL;DR: In this article, the average tube diameter, ranging in size from 25 to 65 nm, was found to increase with increasing anodizing voltage, while the length of the tube was found independent of anodization time.
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Osteoinduction, osteoconduction and osseointegration.
TL;DR: Osseointegration is the stable anchorage of an implant achieved by direct bone-to-implant contact in craniofacial implantology and this mode of anchorage is the only one for which high success rates have been reported.
Journal ArticleDOI
Stem cell fate dictated solely by altered nanotube dimension
TL;DR: Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media.