Journal ArticleDOI
Effects of TiO2 nanotubes with different diameters on gene expression and osseointegration of implants in minipigs.
TLDR
TiO(2) nanotubes can modulate bone formation events at the bone-implant interface as to reach favorable molecular response and osseointegration and the diameters of nanot tubes can be precisely controlled in order to obtain better bone formation.About:
This article is published in Biomaterials.The article was published on 2011-10-01. It has received 279 citations till now. The article focuses on the topics: Osseointegration & Implant.read more
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Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells
Wenjie Zhang,Zihui Li,Yan Liu,Dongxia Ye,Jinhua Li,Lianyi Xu,Bin Wei,Xiuli Zhang,Xuanyong Liu,Xinquan Jiang +9 more
TL;DR: The enhanced adhesion, proliferation, and osteogenic differentiation abilities of rat BMMSCs on the nano-sawtooth structures suggest the potential to induce improvements in bone-titanium integration in vivo.
Journal ArticleDOI
Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies
TL;DR: Investigation of the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo revealed that both NTs and NT-V showed good biOCompatibility, which means the NTsloaded with antibiotic might be potentially used for future orthopedic implants.
Journal ArticleDOI
Dental implants modified with drug releasing titania nanotubes: therapeutic potential and developmental challenges.
Karan Gulati,Saso Ivanovski +1 more
TL;DR: This review focuses on applications of TNT-based dental implants towards achieving optimal therapeutic efficacy, and the functions of TNT implants will be explored in terms of their influence on osseointegration, soft tissue integration and immunomodulation.
Journal ArticleDOI
In situ modulation of crystallinity and nano-structures to enhance the stability and osseointegration of hydroxyapatite coatings on Ti-6Al-4V implants
TL;DR: In this paper, a nanorod-structured HA (nHA) coating with a pure phase and high crystallinity was successfully developed by combining atmospheric plasma spraying (APS) with hydrothermal treatment (HT).
Journal ArticleDOI
Anodization of titanium alloys for orthopedic applications
Merve İzmir,Batur Ercan +1 more
TL;DR: An overview of the anodization technique to grow nanostructured oxide films on titanium and titanium alloys and summarizes the interactions between anodized titanium alloy surfaces with cells in terms of cellular adhesion, proliferation and differentiation is provided in this article.
References
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Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Kazuhisa Nakashima,Xin Zhou,Gary R. Kunkel,Zhaoping Zhang,Jian Min Deng,Richard R. Behringer,Benoit de Crombrugghe +6 more
TL;DR: It is proposed that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells, because Osx null preostEoblasts express typical chondrocyte marker genes, and Osx acts downstream of Runx 2/C bfa1.
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Titanium oxide nanotube arrays prepared by anodic oxidation
Dawei Gong,Craig A. Grimes,Oomman K. Varghese,Wenchong Hu,R. S. Singh,Zhi Chen,Elizabeth C. Dickey +6 more
TL;DR: In this article, the average tube diameter, ranging in size from 25 to 65 nm, was found to increase with increasing anodizing voltage, while the length of the tube was found independent of anodization time.
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Osteoinduction, osteoconduction and osseointegration.
TL;DR: Osseointegration is the stable anchorage of an implant achieved by direct bone-to-implant contact in craniofacial implantology and this mode of anchorage is the only one for which high success rates have been reported.
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Stem cell fate dictated solely by altered nanotube dimension
TL;DR: Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media.