Journal ArticleDOI
Effects of TiO2 nanotubes with different diameters on gene expression and osseointegration of implants in minipigs.
TLDR
TiO(2) nanotubes can modulate bone formation events at the bone-implant interface as to reach favorable molecular response and osseointegration and the diameters of nanot tubes can be precisely controlled in order to obtain better bone formation.About:
This article is published in Biomaterials.The article was published on 2011-10-01. It has received 279 citations till now. The article focuses on the topics: Osseointegration & Implant.read more
Citations
More filters
Journal ArticleDOI
Adverse Biological Effect of TiO2 and Hydroxyapatite Nanoparticles Used in Bone Repair and Replacement
TL;DR: Inhibition of the oxidative stress response and signaling transduction may be a new therapeutic strategy for wear debris–mediated osteolysis and developing biomimetic materials with better biocompatibility is the goal for orthopedic implants.
Journal ArticleDOI
Nanoantibiotics: a new paradigm for the treatment of surgical infection
Joseph S. Fernandez-Moure,Michael Evangelopoulos,Kayla Colvill,Jeffrey L. Van Eps,Ennio Tasciotti +4 more
TL;DR: In this review, treatment methods of orthopedic-device-related infections will be discussed and an overview of antimicrobial-based nanotechnologies will be provided.
Journal ArticleDOI
The controlled release of simvastatin from TiO2 nanotubes to promote osteoblast differentiation and inhibit osteoclast resorption
TL;DR: In this paper, a novel drug-releasing bioactive platform that has excellent potential for improving osteoblast differentiation and inhibiting osteoclast resorption was fabricated by an anodization method.
Journal ArticleDOI
Effect of crystalline phase changes in titania (TiO2) nanotube coatings on platelet adhesion and activation
TL;DR: The TNT coatings annealed at 450°C resulted in the most improved platelet behavior and the TNT crystalline phase was the predominant influencing factor in platelet adhesion and activation.
Journal ArticleDOI
Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO 2 Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy
Yangmengfan Chen,Ming Guan,Ranyue Ren,Chenghao Gao,Hao Cheng,Yong Li,Biao Gao,Yong Wei,Jijiang Fu,Jun Sun,Wei Xiong +10 more
TL;DR: It is suggested that Ag@TiO2-NTs with controlled releasing of ultra-low-dose Ag+ ions could not only inhibit the inflammation process but also promote the bone healing by inducing healing-associated M2 polarization.
References
More filters
Journal ArticleDOI
Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
Journal ArticleDOI
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
Kazuhisa Nakashima,Xin Zhou,Gary R. Kunkel,Zhaoping Zhang,Jian Min Deng,Richard R. Behringer,Benoit de Crombrugghe +6 more
TL;DR: It is proposed that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells, because Osx null preostEoblasts express typical chondrocyte marker genes, and Osx acts downstream of Runx 2/C bfa1.
Journal ArticleDOI
Titanium oxide nanotube arrays prepared by anodic oxidation
Dawei Gong,Craig A. Grimes,Oomman K. Varghese,Wenchong Hu,R. S. Singh,Zhi Chen,Elizabeth C. Dickey +6 more
TL;DR: In this article, the average tube diameter, ranging in size from 25 to 65 nm, was found to increase with increasing anodizing voltage, while the length of the tube was found independent of anodization time.
Journal ArticleDOI
Osteoinduction, osteoconduction and osseointegration.
TL;DR: Osseointegration is the stable anchorage of an implant achieved by direct bone-to-implant contact in craniofacial implantology and this mode of anchorage is the only one for which high success rates have been reported.
Journal ArticleDOI
Stem cell fate dictated solely by altered nanotube dimension
TL;DR: Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media.