Journal ArticleDOI
Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages
Montserrat Estruch,Kristiina Rajamäki,José Luis Sánchez-Quesada,Petri T. Kovanen,Katariina Öörni,Sonia Benitez,Jordi Ordóñez-Llanos +6 more
TLDR
LDL(−) promotes release of biologically active IL-1β in monocytes and MDM by induction of the two steps involved: priming and NLRP3 inflammasome activation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2015-11-01. It has received 37 citations till now. The article focuses on the topics: Receptor complex.read more
Citations
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Journal ArticleDOI
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
TL;DR: In advanced atherosclerotic lesions, the ratio between specialized pro-resolving mediators and pro-inflammatory lipids is strikingly low, providing a molecular explanation for the defective inflammation resolution features of these lesions.
Journal ArticleDOI
Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties
Satu Lehti,Su D. Nguyen,Ilya Belevich,Helena Vihinen,Hanna M. Heikkilä,Rabah Soliymani,Reijo Käkelä,Jani Saksi,Matti Jauhiainen,Matti Jauhiainen,Gregory A. Grabowski,Outi Kummu,Sohvi Hörkkö,Sohvi Hörkkö,Marc Baumann,Perttu J. Lindsberg,Eija Jokitalo,Petri T. Kovanen,Katariina Öörni +18 more
TL;DR: 3D electron microscopy revealed extracellular lipids accumulate in human carotid plaques as distinct 3D structures that include aggregated and fused lipoprotein particles and cholesterol crystals, indicating involvement of lipolytic enzymes in their generation.
Journal ArticleDOI
L5-LDL from ST-elevation myocardial infarction patients induces IL-1β production via LOX-1 and NLRP3 inflammasome activation in macrophages
TL;DR: The results showed that L5-LDL induced activation of caspase-1 and NF-κB through the lectin-type oxidized LDL receptor (LOX-1)-dependent pathway, leading to the production of IL-1β.
Journal ArticleDOI
Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells.
Rafael Corrêa,Luís Felipe Fonseca Silva,Dalila Juliana S. Ribeiro,Raquel das Neves Almeida,Igor de Oliveira Santos,Luís Henrique Corrêa,Lívia Pimentel de Sant'Ana,Leonardo Santos Assunção,Patrícia T. Bozza,Kelly Grace Magalhães +9 more
TL;DR: The results showed that LPC induced foam cell formation in both types of cells by increasing LD biogenesis via a NLRP3 inflammasome-dependent pathway and the IL-1β secretion and foamcell formation triggered by LPC via an inflammaome-mediated pathway in human monocytes and endothelial cells.
Journal ArticleDOI
The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages.
Wenyun Zeng,Danbin Wu,Yingxin Sun,Yanrong Suo,Qun Yu,Miao Zeng,Qing Gao,Bin Yu,Xijuan Jiang,Yijing Wang +9 more
TL;DR: In this article, a selective NLRP3 inhibitor, MCC950, was injected to 8-week-old apoE−/− mice fed with high-fat diet for 12 weeks.
References
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Journal ArticleDOI
Sterile inflammation: sensing and reacting to damage
Grace Y. Chen,Gabriel Núñez +1 more
TL;DR: The triggers and receptor pathways that result in sterile inflammation and its impact on human health are reviewed.
Journal ArticleDOI
Interleukin-1 and interleukin-1 antagonism.
TL;DR: The recent cloning of a naturally occurring IL-1 receptor antagonist (IL-1ra) has opened new experimental and clinical approaches and reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells.
Journal ArticleDOI
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Bolormaa Vandanmagsar,Yun-Hee Youm,Anthony Ravussin,Jose E. Galgani,Krisztian Stadler,Randall L. Mynatt,Eric Ravussin,Jacqueline M. Stephens,Vishwa Deep Dixit +8 more
TL;DR: It is established that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well as with decreased inflammation and improved insulin sensitivity, and that the NlrP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.
Journal ArticleDOI
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
TL;DR: This review summarizes acute and chronic inflammatory diseases that are treated by reducing IL-1β activity and proposes that disease severity is affected by the anti-inflammatory members of the IL- 1 family of ligands and receptors.
Journal ArticleDOI
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.
Sanjeev Mariathasan,Kim Newton,Denise M. Monack,Domagoj Vucic,Dorothy French,Wyne P. Lee,Meron Roose-Girma,Sharon Erickson,Vishva M. Dixit +8 more
TL;DR: Interestingly, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways.
Related Papers (5)
Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Peter Duewell,Hajime Kono,Katey J. Rayner,Katey J. Rayner,Cherilyn M. Sirois,Gregory I. Vladimer,Franz Bauernfeind,George S. Abela,Luigi Franchi,Guillermo Gabriel Nuñez,Max Schnurr,Terje Espevik,Egil Lien,Katherine A. Fitzgerald,Kenneth L. Rock,Kathryn J. Moore,Kathryn J. Moore,Samuel D. Wright,Veit Hornung,Eicke Latz,Eicke Latz +20 more