Emerging Role of Eukaryote Ribosomes in Translational Control.
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TLDR
How technological advances have participated in the emergence of the concept of “specialized ribosomes”, and to which extent the literature sustains this concept today are presented.Abstract:
Translation is one of the final steps that regulate gene expression. The ribosome is the effector of translation through to its role in mRNA decoding and protein synthesis. Many mechanisms have been extensively described accounting for translational regulation. However it emerged only recently that ribosomes themselves could contribute to this regulation. Indeed, though it is well-known that the translational efficiency of the cell is linked to ribosome abundance, studies recently demonstrated that the composition of the ribosome could alter translation of specific mRNAs. Evidences suggest that according to the status, environment, development, or pathological conditions, cells produce different populations of ribosomes which differ in their ribosomal protein and/or RNA composition. Those observations gave rise to the concept of "specialized ribosomes", which proposes that a unique ribosome composition determines the translational activity of this ribosome. The current review will present how technological advances have participated in the emergence of this concept, and to which extent the literature sustains this concept today.read more
Citations
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Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
Schraga Schwartz,Douglas A. Bernstein,Maxwell R. Mumbach,Marko Jovanovic,Rebecca H. Herbst,Brian X. León-Ricardo,Jesse M. Engreitz,Mitchell Guttman,Rahul Satija,Eric S. Lander,Gerald R. Fink,Aviv Regev,Aviv Regev,Aviv Regev +13 more
TL;DR: This work identifies an enhanced, transcriptome-wide scope for pseudouridine and methods to dissect its underlying mechanisms and function and discovers hundreds of unique sites in human and yeast mRNAs and snoRNAs.
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Rajiv K. Khajuria,Rajiv K. Khajuria,Rajiv K. Khajuria,Mathias Munschauer,Jacob C. Ulirsch,Jacob C. Ulirsch,Claudia Fiorini,Claudia Fiorini,Leif S. Ludwig,Leif S. Ludwig,Sean K. McFarland,Sean K. McFarland,Nour J. Abdulhay,Nour J. Abdulhay,Harrison Specht,Hasmik Keshishian,D. R. Mani,Marko Jovanovic,Steven R. Ellis,Charles P. Fulco,Jesse M. Engreitz,Sabina Schütz,John Lian,John Lian,Karen W. Gripp,Olga K. Weinberg,Geraldine S. Pinkus,Lee Gehrke,Lee Gehrke,Aviv Regev,Eric S. Lander,Hanna T. Gazda,Hanna T. Gazda,Winston Y. Lee,Vikram Govind Panse,Steven A. Carr,Vijay G. Sankaran,Vijay G. Sankaran +37 more
TL;DR: It is shown how the reduced translation of select transcripts in HSPCs can impair erythroid lineage commitment, illuminating a regulatory role for ribosome levels in cellular differentiation.
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Regulation of ribosomal protein genes: An ordered anarchy
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Controlling Apomixis: Shared Features and Distinct Characteristics of Gene Regulation
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Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies.
Arnaud Gilles,Léo Frechin,Kundhavai S. Natchiar,Giulia Biondani,Ottilie von Loeffelholz,Samuel Holvec,Julie-Lisa Malaval,Jean-Yves Winum,Bruno P. Klaholz,Jean-François Peyron +9 more
TL;DR: The role of the human ribosome as a medical target in cancer, how functional and structural analysis combined with chemical synthesis of new inhibitors can synergize, and the possible existence of oncoribosomes are discussed.
References
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Journal ArticleDOI
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
TL;DR: A ribosomesome-profiling strategy based on the deep sequencing of ribosome-protected mRNA fragments is presented and enables genome-wide investigation of translation with subcodon resolution and is used to monitor translation in budding yeast under both rich and starvation conditions.
Journal ArticleDOI
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
TL;DR: Current understanding of the major factors regulating protein expression is summarized to demonstrate a substantial role for regulatory processes occurring after mRNA is made in controlling steady-state protein abundances.
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
The mechanism of eukaryotic translation initiation and principles of its regulation
TL;DR: This work has provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
Journal ArticleDOI
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
TL;DR: It is established that the ribosome is a ribozyme and the catalytic properties of its all-RNA active site are addressed and the mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases.
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