Epidermal stem cell diversity and quiescence
Fiona M. Watt,Kim B. Jensen +1 more
TLDR
New observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis and the stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.Abstract:
Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.read more
Citations
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Journal ArticleDOI
Epithelialization in Wound Healing: A Comprehensive Review
Irena Pastar,Olivera Stojadinovic,Natalie C. Yin,Horacio Ramirez,Aron G. Nusbaum,Andrew P. Sawaya,Shailee Patel,Laiqua Khalid,R. Isseroff,Marjana Tomic-Canic +9 more
TL;DR: The pivotal role of keratinocytes in epithelialization is focused on, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing.
Journal ArticleDOI
Modulating the stem cell niche for tissue regeneration
TL;DR: It is envisaged that successful treatments in regenerative medicine will involve different combinations of factors to target stem cells and niche cells, applied at different times to effect recovery according to the dynamics of stem cell–niche interactions.
Journal ArticleDOI
Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
Isaac Brownell,Elizabeth Guevara,C. Brian Bai,Cynthia A. Loomis,Alexandra L. Joyner,Alexandra L. Joyner +5 more
TL;DR: Nerves cultivate a microenvironment where Shh creates a molecularly and phenotypically distinct population of hair follicle stem cells that incorporate into healing skin wounds where, notably, they can change their lineage into epidermal stem cells.
Journal ArticleDOI
Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease
Jason R. Rock,Brigid L.M. Hogan +1 more
TL;DR: The development, maintenance, and repair of the vertebrate respiratory system is reviewed with an emphasis on the roles of epithelial stem and progenitor cells.
Journal ArticleDOI
Cutaneous wound healing: recruiting developmental pathways for regeneration
TL;DR: The varying responses to cutaneous injury across the taxa are discussed, ranging from complete regeneration to scar tissue formation, and research into the role of developmental pathways during skin repair has contributed to current wound therapies, and holds potential for the development of more effective treatments.
References
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Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis
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Tudorita Tumbar,Géraldine Guasch,Valentina Greco,Cédric Blanpain,William E. Lowry,Michael Rendl,Elaine Fuchs +6 more
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Journal ArticleDOI
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