Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer.
Johannes Brägelmann,Johannes Brägelmann,Carol Barahona Ponce,Carol Barahona Ponce,Katherine Marcelain,Stephanie Roessler,Benjamin Goeppert,Iván Gallegos,Alicia Colombo,Verónica Sanhueza,Erik Morales,María Teresa Rivera,Gonzalo de Toro,Alejandro Ortega,Bettina Müller,Fernando Gabler,Dominique Scherer,Melanie Waldenberger,Eva Reischl,Felix Boekstegers,Valentina Garate-Calderon,Valentina Garate-Calderon,Sinan Uğur Umu,Trine B. Rounge,Odilia Popanda,Justo Lorenzo Bermejo +25 more
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TLDR
This study investigates the epigenetic changes along the model of GBC carcinogenesis represented by the sequence gallstone disease → dysplasia → GBC in Chile, the country with the highest incidence of G BC worldwide.About:
This article is published in Hepatology.The article was published on 2021-06-01 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Dysplasia & DNA methylation.read more
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EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study.
Zhuang Xiong,Zhuang Xiong,Fei Yang,Fei Yang,Mengwei Li,Yingke Ma,Wei Zhao,Wei Zhao,Guo-Liang Wang,Guo-Liang Wang,Zhaohua Li,Zhaohua Li,Xinchang Zheng,Dong Zou,Wenting Zong,Wenting Zong,Hongen Kang,Hongen Kang,Yaokai Jia,Rujiao Li,Zhang Zhang,Zhang Zhang,Yiming Bao,Yiming Bao +23 more
TL;DR: In this paper, the authors present EWAS Open Platform (https://ngdc.cncb.ac.cn/ewas) that includes EWAS Atlas, EWAS Data Hub and the newly developed EWAS Toolkit.
Journal ArticleDOI
Gallbladder cancer
TL;DR: This PrimeView highlights the mechanisms of gallbladder cancer and summarizes its epidemiology, diagnosis and management and accompanies the Primer on this topic by Roa and colleagues.
Journal ArticleDOI
Biliary Tract Cancers: Treatment Updates and Future Directions in the Era of Precision Medicine and Immuno-Oncology
Journal ArticleDOI
Gallbladder cancer
Juan Carlos Roa,Patricia García,Vinay K. Kapoor,Shishir K. Maithel,Milind Javle,Jill Koshiol +5 more
TL;DR: This Primer by Roa and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of gallbladder cancer, and discusses patient quality of life and open research questions for this disease.
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Subtypes of Native American ancestry and leading causes of death
Justo Lorenzo Bermejo,Felix Boekstegers,Rosa González Silos,Carol Barahona Ponce,Christine Fischer,Barbara Peil +5 more
TL;DR: After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, an identified association with gallbladder cancer is validated relying on individual data from 64 gallbladders cancer patients, with and without a family history, and 170 healthy controls.
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