Exosomes and breast cancer drug resistance.
Xingli Dong,Xupeng Bai,Jie Ni,Jie Ni,Hao Zhang,Wei Duan,Peter Graham,Peter Graham,Yong Li,Yong Li,Yong Li +10 more
TLDR
The underlying associations between exosomes and drug resistance of BC are summarized and exosome is proposed as a candidate biomarker in predicting and monitoring the therapeutic drug response of BC and as a potential target or carrier to reverse the drug resistant BC.Abstract:
Drug resistance is a daunting challenge in the treatment of breast cancer (BC). Exosomes, as intercellular communicative vectors in the tumor microenvironment, play an important role in BC progression. With the in-depth understanding of tumor heterogeneity, an emerging role of exosomes in drug resistance has attracted extensive attention. The functional proteins or non-coding RNAs contained in exosomes secreted from tumor and stromal cells mediate drug resistance by regulating drug efflux and metabolism, pro-survival signaling, epithelial–mesenchymal transition, stem-like property, and tumor microenvironmental remodeling. In this review, we summarize the underlying associations between exosomes and drug resistance of BC and discuss the unique biogenesis of exosomes, the change of exosome cargo, and the pattern of release by BC cells in response to drug treatment. Moreover, we propose exosome as a candidate biomarker in predicting and monitoring the therapeutic drug response of BC and as a potential target or carrier to reverse the drug resistance of BC.read more
Citations
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Long non-coding RNAs in the doxorubicin resistance of cancer cells.
Saeed Ashrafizaveh,Milad Ashrafizadeh,Ali Zarrabi,Kiavash Husmandi,Amirhossein Zabolian,Shahinozzaman,Amir Reza Aref,Michael R. Hamblin,Noushin Nabavi,Francesco Crea,Yuzhuo Wang,Kwang Seok Ahn +11 more
Journal ArticleDOI
The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression
TL;DR: The role of TAMs in tumor metastasis was examined in this article, where the microenvironmental factors involved in macrophage polarization and the mechanisms of TAM-mediated tumor metastases were discussed.
Journal ArticleDOI
Circulating extracellular vesicles are effective biomarkers for predicting response to cancer therapy
E. Zhou,Yumei Li,Feng Wu,Mengfei Guo,Juanjuan Xu,Sufei Wang,Qi Tan,Pei Ma,Siwei Song,Yang Jin +9 more
TL;DR: In this article, the potential clinical significance of EVs and their cargos in therapeutic response monitoring and prediction in several cancers (mainly lung cancer, prostate cancer, breast cancer, melanoma, lymphoma, glioblastoma, and head and neck squamous cell carcinoma) and discuss the questions that require future investigation.
Journal ArticleDOI
The roles of tumor-derived exosomes in altered differentiation, maturation and function of dendritic cells
Reza Hosseini,Leila Asef-Kabiri,Hassan Yousefi,Hamzeh Sarvnaz,Majid Salehi,Mohammad Esmaeil Akbari,Nahid Eskandari +6 more
TL;DR: In this article, a mechanistic insight into the TDEs-mediated abnormalities in dendritic cells abnormalities in the tumor context is provided, where the authors discuss extensively how tumor exosomes induce subversion of Dendritic cell differentiation, maturation and function.
Journal ArticleDOI
JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies
Bilal Rah,Rafiq Ahmad Rather,Gh. Rasool Bhat,Abdul Basit Baba,I. Mushtaq,Muzamil Farooq,Tahir Yousuf,Sadaf Bashir Dar,Sabra Parveen,Rukhsana Hassan,Fozia Mohammad,Iqbal Qassim,Abida Bhat,Shazia Ali,Mahrukh Hamid Zargar,Dil Afroze +15 more
TL;DR: A better understanding of the functionally redundant roles of JAKs and STATs may provide a rationale for improving existing cancer therapies which have deleterious effects on normal cells and to identifying novel targets for therapeutic intervention in solid malignancies.
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