Exploring the utility of extracellular vesicles in ameliorating viral infection-associated inflammation, cytokine storm and tissue damage.
TLDR
Extracellular vesicles (EVs) have emerged as potential mediators of intercellular communication as discussed by the authors and hold great promise for therapeutic treatments, particularly in treating a potentially fatal autoimmune response and attenuate inflammation.About:
This article is published in Translational Oncology.The article was published on 2021-04-19 and is currently open access. It has received 14 citations till now.read more
Citations
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Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications
TL;DR: The sources of extracellular vesicles, including plant, salivary and urinary sources which are easily available but less sought after compared with blood and tissue are discussed.
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Diagnostic and Therapeutic Potential of Extracellular Vesicles.
Sai Priyanka Kodam,Mujib Ullah +1 more
TL;DR: Extracellular vesicles (EVs) are naturally phospholipid enclosed nanoveicles released by many cells in the body as discussed by the authors, which are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules.
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Exosome engineering for efficient and targeted drug delivery: Current status and future perspective
TL;DR: Exosomes are membrane-bound vesicles that are released by most cells and carry nucleic acids, cytokines, growth factors, proteins, lipids, and metabolites as discussed by the authors .
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Artificial intelligence and guidance of medicine in the bubble.
TL;DR: In this paper, the advanced bubble-based drug-delivery system, integrated with artificial intelligence for guidance, holds great promise for the targeted delivery of drugs and medicines, which can effectively circulate through the whole body safely and efficiently to reach the target area.
Journal ArticleDOI
Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells
TL;DR: In this article, heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells (iplus) in the presence of heat shock.
References
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.
Alexandra C. Walls,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Abigail Wall,Andrew T. McGuire,Andrew T. McGuire,David Veesler +7 more
TL;DR: It is demonstrating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination, and it is shown that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of Sars- coV- 2 S and SARS S bind with similar affinities to human ACE2, correlating with the efficient spread of SATS among humans.
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The trinity of COVID-19: immunity, inflammation and intervention.
Matthew Zirui Tay,Chek Meng Poh,Laurent Rénia,Laurent Rénia,Paul A. MacAry,Lisa F. P. Ng,Lisa F. P. Ng,Lisa F. P. Ng +7 more
TL;DR: The interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression is described and the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation are highlighted.
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Characteristics of SARS-CoV-2 and COVID-19
TL;DR: The basic virology of SARS-CoV-2 is described, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses.
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Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China.
Aiping Wu,Yousong Peng,Baoying Huang,Xiao Ding,Xianyue Wang,Peihua Niu,Jing Meng,Zhaozhong Zhu,Zheng Zhang,Jiangyuan Wang,Jie Sheng,Lijun Quan,Zanxian Xia,Wenjie Tan,Genhong Cheng,Taijiao Jiang +15 more
TL;DR: An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-n coV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.