Extraintestinal manifestations of inflammatory bowel disease
Stephan R. Vavricka,Alain M. Schoepfer,Michael Scharl,Peter L. Lakatos,Alexander A. Navarini,Gerhard Rogler +5 more
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TLDR
Extraintestinal manifestations in inflammatory bowel disease (IBD) are frequent and may occur before or after IBD diagnosis, and successful therapy of EIM is essential for improving quality of life of patients with IBD.Abstract:
Extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) are frequent and may occur before or after IBD diagnosis. EIM may impact the quality of life for patients with IBD significantly requiring specific treatment depending on the affected organ(s). They most frequently affect joints, skin, or eyes, but can also less frequently involve other organs such as liver, lungs, or pancreas. Certain EIM, such as peripheral arthritis, oral aphthous ulcers, episcleritis, or erythema nodosum, are frequently associated with active intestinal inflammation and usually improve by treatment of the intestinal activity. Other EIM, such as uveitis or ankylosing spondylitis, usually occur independent of intestinal inflammatory activity. For other not so rare EIM, such as pyoderma gangrenosum and primary sclerosing cholangitis, the association with the activity of the underlying IBD is unclear. Successful therapy of EIM is essential for improving quality of life of patients with IBD. Besides other options, tumor necrosis factor antibody therapy is an important therapy for EIM in patients with IBD.read more
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Journal ArticleDOI
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Ying Li,Silvia Innocentin,David R. Withers,Natalie A. Roberts,Alec R. Gallagher,Elena Grigorieva,Christoph Wilhelm,Marc Veldhoen,Marc Veldhoen +8 more
TL;DR: It is shown that the aryl hydrocarbon receptor (AhR) is a crucial regulator in maintaining IEL numbers in both the skin and the intestine, and that AhR deficiency or the lack of AhR ligands compromises the maintenance of IELs and the control of the microbial load and composition.
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European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
Eduard F. Stange,Simon Travis,Severine Vermeire,Walter Reinisch,K. Geboes,A. Barakauskiene,R. Feakins,Jean-François Fléjou,Hans H Herfarth,Daan W. Hommes,Limas Kupčinskas,Peter L. Lakatos,Gerassimos J. Mantzaris,Stefan Schreiber,Vincenzo Villanacci,Bryan F. Warren +15 more
TL;DR: The aim of the Consensus is to promote a European perspective on the management of ulcerative colitis (UC) and its dilemmas and to avoid duplication of effort in the future.
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Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease
TL;DR: The clinical manifestations and diagnostic features of IBD are delineated, and important recent advances in the understanding of the immune mediators of intestinal inflammation are summarized.
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The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study.
TL;DR: The finding of asthma as the most common comorbidity increased in Crohn's disease patients compared with the general population is novel and should encourage further research into the common triggers in the organ systems that lead to autoimmune diseases.
Journal ArticleDOI
Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study
Laszlo Lakatos,Tunde Pandur,Gyula David,Zsuzsanna Balogh,Pal Kuronya,Arpad Tollas,Peter L. Lakatos +6 more
TL;DR: Prevalence of EIM in Hungarian IBD patients is in concordance with data from Western countries, and supports a role for complex follow-up in these patients.
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Journal ArticleDOI
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