Fabrication and In Vitro Evaluation of pH-Sensitive Polymeric Hydrogels as Controlled Release Carriers.
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In this article, the authors developed chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-Co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS).Abstract:
The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.read more
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References
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Journal ArticleDOI
A simple equation for the description of solute release. III. Coupling of diffusion and relaxation
TL;DR: In this paper, a coupled diffusion/relaxation model is presented for general analysis of the release behavior of controlled release systems using a coupled diffusional and relaxation model, and the general form of this equation's exponent is related to the geometric shape of the releasing device through its aspect ratio.
Journal ArticleDOI
Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.
Journal ArticleDOI
Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.
Dong-An Wang,Dong-An Wang,Shyni Varghese,Blanka Sharma,Iossif Strehin,Sara Fermanian,Justin M. Gorham,D. Howard Fairbrother,Brett M. Cascio,Jennifer H. Elisseeff +9 more
TL;DR: The biopolymer chondroitin sulphate, one of the major components of cartilage extracellular matrix, is used to develop a novel bioadhesive that is readily applied and acts quickly and led to mechanical stability of the hydrogel and tissue repair in cartilage defects.
Journal ArticleDOI
Photoresponsive hydrogels for biomedical applications.
TL;DR: Recent developments in photoresponsive hydrogels are reviewed and these new materials are discussed, and their applications in the biomedical field are discussed.
Journal ArticleDOI
Near Infrared Light Triggered Release of Biomacromolecules from Hydrogels Loaded with Upconversion Nanoparticles
TL;DR: It is shown that continuous-wave near-infrared (NIR) light can be used to induce the gel-sol transition and release large, inactive biomacromolecules entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered.