Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?
TLDR
Reports of rapid alterations in FAS activity as well as findings of post-translational modifications of the FAS protein support the notion that dynamic events in addition to transcription impact FAS regulation.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2012-05-01 and is currently open access. It has received 279 citations till now. The article focuses on the topics: Fatty acid synthase & Fatty liver.read more
Citations
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Journal ArticleDOI
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
Bart Everts,Eyal Amiel,Stanley Ching-Cheng Huang,Amber M. Smith,Chih-Hao Chang,Wing Y. Lam,Veronika Redmann,Tori C. Freitas,Julianna Blagih,Gerritje J.W. van der Windt,Maxim N. Artyomov,Russell G. Jones,Erika L. Pearce,Edward J. Pearce +13 more
TL;DR: The rapid induction of glycolytic flux increased within minutes of exposure to TLR agonists and served an essential role in supporting the de novo synthesis of fatty acids for the expansion of the endoplasmic reticulum and Golgi required for the production and secretion of proteins that are integral to DC activation.
OtherDOI
Triglyceride Metabolism in the Liver
TL;DR: The current understanding of fatty acid and triglyceride metabolism in the liver and its regulation in health and disease is described, identifying potential directions for future research.
Journal ArticleDOI
De novo lipogenesis in health and disease.
TL;DR: Therapeutic targeting of this pathway may open a new window of opportunity for combating various lipogenesis-driven pathological conditions - including obesity, cancer and certain viral infections.
Journal ArticleDOI
New insights into the pathophysiology of dyslipidemia in type 2 diabetes
Marja-Riitta Taskinen,Jan Borén +1 more
TL;DR: Recent advances in the understanding of the pathophysiology of diabetic dyslipidemia are reviewed, showing that triglyceride-rich lipoproteins and their remnants are atherogenic.
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De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose.
TL;DR: Whether DNL plays a significant role in the pathogenesis of insulin resistance is yet to be fully elucidated, but it may be that the prevalent products of this synthetic process induce some aspect of hepatic insulin resistance.
References
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Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
TL;DR: These results from a representative sample of US adults show that the metabolic syndrome is highly prevalent and the large numbers of US residents with the metabolic Syndrome may have important implications for the health care sector.
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Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition
TL;DR: Although ATP III identified CVD as the primary clinical outcome of the metabolic syndrome, most people with this syndrome have insulin resistance, which confers increased risk for type 2 diabetes, when diabetes becomes clinically apparent, CVD risk rises sharply.
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High density lipoprotein as a protective factor against coronary heart disease: The Framingham study
TL;DR: The major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease in either men or women and these associations were equally significant even when other lipids and other standard risk factors for coronaryHeart disease were taken into consideration.
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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
Kerry L. Donnelly,Coleman Smith,Sarah Jane Schwarzenberg,Jose Jessurun,Mark D. Boldt,Elizabeth J. Parks +5 more
TL;DR: In this article, the authors quantified the biological sources of hepatic and plasma lipoprotein TAG in NAFLD patients, using stable isotopes for four days to label and track serum nonesterified fatty acids (NEFAs), dietary fatty acids, and those derived from the de novo lipogenesis (DNL) pathway, present in liver tissue and lipid TAG.
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Nonalcoholic fatty liver disease a feature of the metabolic syndrome
Giulio Marchesini,Mara Brizi,Giampaolo Bianchi,Sara Tomassetti,Elisabetta Bugianesi,Marco Lenzi,Arthur J. McCullough,S. Natale,Gabriele Forlani,Nazario Melchionda +9 more
TL;DR: It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.