FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis
Pauline Andreu,Magnus Johansson,Nesrine I. Affara,Ferdinando Pucci,Tingting Tan,Simon Junankar,Lidiya Korets,Julia Lam,David Tawfik,David G. DeNardo,Luigi Naldini,Karin E. de Visser,Michele De Palma,Lisa M. Coussens +13 more
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TLDR
Using the K14-HPV16 mouse model of squamous carcinogenesis, it is reported that B cells and humoral immunity foster cancer development by activating FcGamma receptors (FcgammaRs) on resident and recruited myeloid cells.About:
This article is published in Cancer Cell.The article was published on 2010-02-17 and is currently open access. It has received 522 citations till now. The article focuses on the topics: Inflammation & Carcinogenesis.read more
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
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Protective and pathogenic functions of macrophage subsets
Peter J. Murray,Thomas A. Wynn +1 more
TL;DR: The four stages of orderly inflammation mediated by macrophages are discussed: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis.
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The immune contexture in human tumours: impact on clinical outcome
Wolf H. Fridman,Franck Pagès,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Jérôme Galon +5 more
TL;DR: In this Opinion article, the context-specific nature of infiltrating immune cells can affect the prognosis of patients is discussed.
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Alternative Activation of Macrophages: Mechanism and Functions
TL;DR: In this paper, the authors assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment.
References
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Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
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Fcγ receptors as regulators of immune responses
TL;DR: Recent studies addressing the multifaceted roles of FcRs for IgG (FcγRs) in the immune system are discussed and how this knowledge could be translated into novel therapeutic strategies to treat human autoimmune, infectious or malignant diseases are discussed.
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Paradoxical roles of the immune system during cancer development
TL;DR: The paradoxical role of adaptive and innate leukocytes as crucial regulators of cancer development is examined and recent insights that have been gained by manipulating immune responses in mouse models of de novo and spontaneous tumorigenesis are highlighted.
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Statistical analysis of real-time PCR data
TL;DR: Data quality control and analysis procedures presented here provide statistical elements for the estimation of the relative expression of genes using real-time PCR.
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MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis
TL;DR: The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias and invasive cancers of the epidermis in a mouse model of multi-stage tumorigenesis elicited by HPV16 oncogenes, suggesting inflammatory cells can be coconspirators in carcinogenesis.
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