Journal ArticleDOI
Guideline for the laboratory diagnosis of functional iron deficiency.
TLDR
One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).Abstract:
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).read more
Citations
More filters
Journal ArticleDOI
Iron-deficiency anemia.
TL;DR: A review of the global nature of the disease, iron homeostasis in normal and iron-deficient states, clinical findings, treatment, and causes of iron-resistant iron deficiency is given in this article.
Journal ArticleDOI
Iron deficiency anaemia
TL;DR: The clinical presentation, epidemiology, pathophysiology, diagnosis, and acute management of iron deficiency anaemia, and outstanding research questions for treatment are discussed.
Journal ArticleDOI
Biomarkers of Nutrition for Development (BOND)-Iron Review.
Sean Lynch,Christine M. Pfeiffer,Michael K. Georgieff,Gary M. Brittenham,Susan J. Fairweather-Tait,Richard F. Hurrell,Harry J. McArdle,Daniel J Raiten +7 more
TL;DR: A full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers and their interpretation across a range of clinical and population-based uses are provided.
Journal ArticleDOI
International consensus statement on the peri-operative management of anaemia and iron deficiency.
Manuel Muñoz,Austin G. Acheson,M Auerbach,Martin Besser,O Habler,Henrik Kehlet,Giancarlo M. Liumbruno,Sigismond Lasocki,Patrick Meybohm,R. Rao Baikady,Toby Richards,Aryeh Shander,C. So‐Osman,Donat R. Spahn,Andrea Klein +14 more
TL;DR: A diagnostic approach for anaemia and iron deficiency in surgical patients; identification of patients appropriate for treatment; and advice on practical management and follow‐up are developed.
Journal ArticleDOI
Iron deficiency anaemia revisited
TL;DR: This review provides recent updates and guidance on the diagnosis and management of iron deficiency anaemia in multiple clinical settings.
References
More filters
Journal ArticleDOI
HLA-DR4-Ala74β is associated with risk and poor outcome of severe aplastic anemia
TL;DR: Examination of the clinical records has shown that the HLA-DR4-Ala74β subtype is associated with poor outcome of SAA, and multiple comparison analysis confirmed that the DB1*1501 allele confers susceptibility to SAA independently from the DRB1-DR2 allele.
Journal ArticleDOI
Intra-individual variability of serum hepcidin-25 in haemodialysis patients using mass spectrometry and ELISA
Hilde P.E. Peters,Adam Rumjon,Sukhvinder S. Bansal,Coby M. Laarakkers,Jan A.J.G. van den Brand,Pantelis Sarafidis,Rebecca Musto,Jolanta Malyszko,Dorine W. Swinkels,Jack F.M. Wetzels,Iain C. Macdougall +10 more
TL;DR: Inflammation and the use of iron did not impact on the degree of variability, and hepcidin levels were higher after an inter-dialytic period of 3 versus 2 days, which need to be taken into account in future studies assessing the utility of serum hePCidin as a guide to theuse of iron or erythropoiesis-stimulating agents therapy.
Journal ArticleDOI
Parenteral Iron Therapy in Cancer-Associated Anemia
TL;DR: Developing evidence now suggests that, similar to chronic renal failure patients on hemodialysis, the addition of intravenous iron can improve the response to ESA because of iron-restricted erythropoiesis, even in the iron-replete patient.
Journal ArticleDOI
Sensitivity and Specificity of Transferrin Saturation and Serum Ferritin as Markers of Iron Status After Intravenous Iron Dextran in Hemodialysis Patients
TL;DR: Both TS and SF are non-specific and insensitive indicators for accurate diagnosis of iron deficiency in hemodialysis patients in EPO, and there was a statistically significant increase in Hct 4 weeks after i.d. administration.
Journal ArticleDOI
Making Sense: A Scientific Approach to Intravenous Iron Therapy
TL;DR: Fifty yr ago, carbohydrate was first coupled to iron oxide and reducing the fierce toxicity of ferric iron and introducing the era of parenteral therapy with carbohydrate-iron agents.