Journal ArticleDOI
Guideline for the laboratory diagnosis of functional iron deficiency.
TLDR
One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).Abstract:
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).read more
Citations
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Journal ArticleDOI
Reference Values of Reticulocyte Hemoglobin Content in Healthy Adolescents.
María Mercedes Ibáñez-Alcalde,María A Vázquez-López,Ana M. Ruíz-Sánchez,Francisco Lendinez-Molinos,Rafael Galera-Martínez,Antonio Bonillo-Perales,Tesifón Parrón-Carreño +6 more
TL;DR: This study provides CHr reference ranges in healthy adolescents for use in clinical practice for the early detection of ID states and concludes that values above the 2.5 percentile rule out ID, as values under the 2-5 percentile could be suggestive of functional ID.
Journal ArticleDOI
Comment on: Evaluation of erythrocyte and reticulocyte parameters as indicative of iron deficiency in patients with anemia of chronic disease.
TL;DR: Though automated flow cytometric analysis has led to a ignificant advance in reticulocyte counting, some limitaions still persist in comparability across different laboratories.
Journal ArticleDOI
The Reticulocyte Hemoglobin Equivalent as a Screening Marker for Iron Deficiency and Iron Deficiency Anemia in Children
Vanessa Neef,Elke Schmitt,Peter Bader,Frank Zierfuß,Gudrun Hintereder,Andrea U. Steinbicker,Kai Zacharowski,Florian Piekarski +7 more
TL;DR: The reticulocyte hemoglobin equivalent (Ret-He) provides information about the current availability of iron in erythropoiesis and can be used as a single screening parameter for ID and IDA in children without considering other iron parameters as mentioned in this paper.
Journal ArticleDOI
Diagnosis, Treatment and Prevention of Nutritional Anemia in Children: Recommendations of the Joint Committee of Pediatric Hematology-Oncology Chapter and Pediatric and Adolescent Nutrition Society of the Indian Academy of Pediatrics
Jagdish Chandra,Pooja Dewan,Praveen Kumar,Amita Mahajan,Preet Inder Singh,Bhavna Dhingra,Nita Radhakrishnan,Ratna Sharma,Mamta Manglani,Ashok Rawat,Piyush Gupta,Sunil Gomber,Sunil Bhat,Parag Gaikwad,K E Elizabeth,Deepak Bansal,Anand Prakash Dubey,Nitin Shah,Pranoti Kini,Amita Trehan,K. Datta,GV Basavraja,Vineet Saxena,Remesh Kumar +23 more
TL;DR: These guidelines have been developed by the experts from the Pediatric Hematology-Oncology Chapter and thePediatric and Adolescent Nutrition Society of the Indian Academy of Pediatrics to formulate guidelines for diagnosis, treatment and prevention of nutritional anemia in children.
References
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Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
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Journal ArticleDOI
KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease.
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Journal ArticleDOI
Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure.
Francesco Locatelli,Pedro Aljama,Peter Bárány,Bernard Canaud,Fernando Carrera,Kai-Uwe Eckardt,Walter H. Hörl,Iain C Macdougal,Alison M. MacLeod,Andrzej Wiecek,Stewart Cameron +10 more
Journal ArticleDOI
Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency.
TL;DR: In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.