Journal ArticleDOI
Guideline for the laboratory diagnosis of functional iron deficiency.
TLDR
One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).Abstract:
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).read more
Citations
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Journal ArticleDOI
Perioperative anemia management in colorectal cancer patients: A pragmatic approach
TL;DR: Anemia, usually due to iron deficiency, is highly prevalent among patients with colorectal cancer, and a multidisciplinary, multimodal, individualized strategy used to minimize or eliminate allogeneic blood transfusion is indicated to improve outcomes.
Journal ArticleDOI
Pre-operative anaemia.
TL;DR: The incidence and impact of anaemia on the pre‐operative patient is reviewed, how anaemia may be caused by functional iron deficiency, and how iron deficiency anaemia might be diagnosed and treated are explained.
Journal ArticleDOI
Non‐anaemic iron deficiency – a disease looking for recognition of diagnosis: a systematic review
Jeremy John Pratt,Khalid S. Khan +1 more
TL;DR: To capture all data meeting a rigid definition of non‐anaemic iron deficiency (NAID) and determine whether it is associated with poor outcomes compared with normal iron status and whether iron supplementation improves outcomes in NAID.
Journal ArticleDOI
Current misconceptions in diagnosis and management of iron deficiency.
Manuel Muñoz,Susana Gómez-Ramírez,Martin Besser,José Pavia,Fernando Gomollón,Giancarlo M. Liumbruno,Sunil Bhandari,Mercé Cladellas,Aryeh Shander,Michael Auerbach +9 more
TL;DR: The intent of the authors is to provide a consensus that effectively challenges misconceptions, and to highlight evidence-based alternatives for appropriate management, and it is believed that this approach to the management of iron deficiency may be beneficial for both patients and healthcare systems.
Book ChapterDOI
Transferrin Saturation: A Body Iron Biomarker.
TL;DR: Beyond its usual clinical use, an emerging body of evidence has linked TSAT levels to major clinical outcomes such as cardiovascular mortality, which has the potential to extend the utility of TSAT index to risk stratification and prognostication.
References
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Journal Article
K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification
Andrew S. Levey,Josef Coresh,Kline Bolton,Bruce Culleton,Kathy Schiro Harvey,T. Alp Ikizler,Cynda Ann Johnson,Annamaria T. Kausz,Paul L. Kimmel,John W. Kusek,Adeera Levin,Kenneth L. Minaker,Robert Nelson,Helmut G. Rennke,Michael Steffes,Beth Witten,Ronald J. Hogg,Susan Furth,Kevin V. Lemley,Ronald J. Portman,George Schwartz,Joseph Lau,Ethan M Balk,Ronald D. Perrone,Tauqeer Karim,Lara Rayan,Inas Al-Massry,Priscilla Chew,Brad C. Astor,Deirdre De Vine,Garabed Eknoyan,Nathan W. Levin,Sally Burrows-Hudson,William F. Keane,Alan S. Kliger,Derrick Latos,Donna Mapes,Edith Oberley,Kerry Willis,George R. Bailie,Gavin J. Becker,Jerrilynn Burrowes,David Churchill,Allan J. Collins,William Couser,Dick DeZeeuw,Alan Garber,Thomas Golper,Frank A. Gotch,Antonio M. Gotto,Joel W. Greer,Richard H. Grimm,Ramon G. Hannah,Jaime Herrera Acosta,Ronald J. Hogg,Lawrence G. Hunsicker,Michael J. Klag,Saulo Klahr,Caya Lewis,Edmund G. Lowrie,Arthur J. Matas,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith Norris,William F. Owen,Thakor G. Patel,Glenda Payne,Rosa A. Rivera-Mizzoni,David A. Smith,Robert A. Star,Theodore Steinman,Fernando Valderrábano,John Walls,Jean Pierre Wauters,Nanette Wenger,Josephine P. Briggs +78 more
TL;DR: In the early 1990s, the National Kidney Foundation (K/DOQI) developed a set of clinical practice guidelines to define chronic kidney disease and to classify stages in the progression of kidney disease.
Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
Journal ArticleDOI
KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease.
TL;DR: This chapter discusses clinical practice guidelines and recommendations for treatment of anemia in children and adults with Kidney Kidney disease, as well as specific cases of patients with HD-CKD.
Journal ArticleDOI
Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure.
Francesco Locatelli,Pedro Aljama,Peter Bárány,Bernard Canaud,Fernando Carrera,Kai-Uwe Eckardt,Walter H. Hörl,Iain C Macdougal,Alison M. MacLeod,Andrzej Wiecek,Stewart Cameron +10 more
Journal ArticleDOI
Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency.
TL;DR: In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.