Journal ArticleDOI
Guideline for the laboratory diagnosis of functional iron deficiency.
TLDR
One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).Abstract:
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).read more
Citations
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Journal ArticleDOI
Iron Bisglycinate Chelate and Polymaltose Iron for the Treatment of Iron Deficiency Anemia: A Pilot Randomized Trial
TL;DR: Preliminary evidence is provided to suggest a greater efficacy of FeBC than FeP in increasing iron stores in increasing Iron Deficiency Anemia children.
Journal ArticleDOI
Clinical use of low haemoglobin density, transferrin saturation, bone marrow morphology, Perl's stain and other plasma markers in the identification of treatable anaemia presenting for cardiac surgery in a prospective cohort study
Pedro Martin-Cabrera,Matthew Hung,E. Ortmann,Toby Richards,Marcus Ghosh,Fiona Bottrill,Timothy Collier,Andrew A. Klein,Martin Besser +8 more
TL;DR: LHD was superior to hepcidin and bone marrow iron stores in identifying patients with ACD and associated iron deficiency, which would potentially benefit from parenteral iron therapy.
Journal ArticleDOI
Intravenous Iron Therapy in Patients Undergoing Cardiovascular Surgery: A Narrative Review.
TL;DR: In patients undergoing cardiac surgery, IV iron may decrease postoperative anemia, allogenic red blood cell (RBC) transfusion requirement, and mortality, and newer preparations of IV iron appear to be safer and are effective in increasing erythropoiesis.
Journal ArticleDOI
Diagnóstico y tratamiento del déficit de hierro, con o sin anemia, pre y poscirugía bariátrica
Carlos Jericó,Irene Bretón,Amador García Ruiz de Gordejuela,Ana Carla de Oliveira,Miguel A. Rubio,Francisco J. Tinahones,Josep Vidal,Nuria Vilarrasa +7 more
TL;DR: El objetivo of the presente revision es elaborar unos esquemas de diagnostico y tratamiento del deficit de hierro y the anemia ferropenica en el pre and postoperatorio of the cirugia bariatrica.
Journal ArticleDOI
The Association Between Anemia of Chronic Inflammation and Alzheimer's Disease and Related Dementias
Alexander Andreev,Alexander Andreev,Burak Erdinc,Kiran Shivaraj,Julia Schmutz,Olga Levochkina,Dhrity Bhowmik,Fady Farag,Kelli M. Money,Louis H. Primavera,Vladimir Gotlieb,Sonu Sahni,Sonu Sahni,Sonu Sahni +13 more
TL;DR: A retrospective case-control study of patients diagnosed with ADRD demonstrated an association between ADRD and anemia of chronic inflammation independent of age, renal function, and HgbA1C levels.
References
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Journal Article
K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification
Andrew S. Levey,Josef Coresh,Kline Bolton,Bruce Culleton,Kathy Schiro Harvey,T. Alp Ikizler,Cynda Ann Johnson,Annamaria T. Kausz,Paul L. Kimmel,John W. Kusek,Adeera Levin,Kenneth L. Minaker,Robert Nelson,Helmut G. Rennke,Michael Steffes,Beth Witten,Ronald J. Hogg,Susan Furth,Kevin V. Lemley,Ronald J. Portman,George Schwartz,Joseph Lau,Ethan M Balk,Ronald D. Perrone,Tauqeer Karim,Lara Rayan,Inas Al-Massry,Priscilla Chew,Brad C. Astor,Deirdre De Vine,Garabed Eknoyan,Nathan W. Levin,Sally Burrows-Hudson,William F. Keane,Alan S. Kliger,Derrick Latos,Donna Mapes,Edith Oberley,Kerry Willis,George R. Bailie,Gavin J. Becker,Jerrilynn Burrowes,David Churchill,Allan J. Collins,William Couser,Dick DeZeeuw,Alan Garber,Thomas Golper,Frank A. Gotch,Antonio M. Gotto,Joel W. Greer,Richard H. Grimm,Ramon G. Hannah,Jaime Herrera Acosta,Ronald J. Hogg,Lawrence G. Hunsicker,Michael J. Klag,Saulo Klahr,Caya Lewis,Edmund G. Lowrie,Arthur J. Matas,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith Norris,William F. Owen,Thakor G. Patel,Glenda Payne,Rosa A. Rivera-Mizzoni,David A. Smith,Robert A. Star,Theodore Steinman,Fernando Valderrábano,John Walls,Jean Pierre Wauters,Nanette Wenger,Josephine P. Briggs +78 more
TL;DR: In the early 1990s, the National Kidney Foundation (K/DOQI) developed a set of clinical practice guidelines to define chronic kidney disease and to classify stages in the progression of kidney disease.
Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
Journal ArticleDOI
KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease.
TL;DR: This chapter discusses clinical practice guidelines and recommendations for treatment of anemia in children and adults with Kidney Kidney disease, as well as specific cases of patients with HD-CKD.
Journal ArticleDOI
Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure.
Francesco Locatelli,Pedro Aljama,Peter Bárány,Bernard Canaud,Fernando Carrera,Kai-Uwe Eckardt,Walter H. Hörl,Iain C Macdougal,Alison M. MacLeod,Andrzej Wiecek,Stewart Cameron +10 more
Journal ArticleDOI
Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency.
TL;DR: In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.