Journal ArticleDOI
Guideline for the laboratory diagnosis of functional iron deficiency.
TLDR
One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).Abstract:
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).read more
Citations
More filters
Journal ArticleDOI
Metabolic surgery and iron homeostasis
Peter N. Benotti,G. Craig Wood,Christopher D. Still,Glenn S. Gerhard,David D. K. Rolston,Bruce R. Bistrian +5 more
TL;DR: Current mechanisms concerning the pathogenesis of disordered iron nutrition in patients with severe obesity, current gaps in knowledge, and opportunities for quality improvement are outlined.
Journal ArticleDOI
Severe anemia after Roux-en-Y gastric bypass: a cause for concern.
Emily McCracken,G. Craig Wood,Wesley Prichard,Bruce R. Bistrian,Christopher D. Still,Glenn S. Gerhard,David D. K. Rolston,Peter N. Benotti +7 more
TL;DR: The long-term incidence of clinically significant anemia after Roux-en-Y gastric bypass is alarmingly high and warrants more detailed study.
Journal ArticleDOI
Associations between non-anaemic iron deficiency and outcomes following elective cardiac surgery (IDOCS): a prospective cohort study.
Lachlan F Miles,Vanessa Pac Soo,Sabine Braat,Jordan Bade-Boon,Stephane Heritier,Andrew S. Klein,Paul S. Myles,Toby Richards,Joel Ari Symons,Kate Burbury,David A Story +10 more
TL;DR: In this article , the authors performed a prospective, cohort study at two hospitals in Australia and found that non-anaemic iron deficiency is associated with worse postoperative outcomes than an iron replete state in adults undergoing elective cardiac surgery.
Journal ArticleDOI
Role of Soluble Transferrin Receptor and Transferrin Receptor-Ferritin Index to Detect Iron Deficiency Anemia in Regular Hemodialysis Patients.
TL;DR: When sTfR and the TfR-F index used in combination to detect IDA is found, the largest AUC on ROC 0.98 (95% CI 0.94-1.00) is found more superior than stfR, and sTFR and TfF index mean level was different between IDA and ACD patients although not statistically significant.
Journal ArticleDOI
Anemia and iron-restricted erythropoiesis in traumatic critical illness.
TL;DR: Electronic databases covering 1980 to 2015 (MEDLINE, EMBASE, Cochrane Library) were included in the literature review and articles focusing on critically ill patients, trauma, anemia, iron-restricted erythropoiesis (IRE), hepcidin, iron, and EPO were identified and reviewed.
References
More filters
Journal Article
K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification
Andrew S. Levey,Josef Coresh,Kline Bolton,Bruce Culleton,Kathy Schiro Harvey,T. Alp Ikizler,Cynda Ann Johnson,Annamaria T. Kausz,Paul L. Kimmel,John W. Kusek,Adeera Levin,Kenneth L. Minaker,Robert Nelson,Helmut G. Rennke,Michael Steffes,Beth Witten,Ronald J. Hogg,Susan Furth,Kevin V. Lemley,Ronald J. Portman,George Schwartz,Joseph Lau,Ethan M Balk,Ronald D. Perrone,Tauqeer Karim,Lara Rayan,Inas Al-Massry,Priscilla Chew,Brad C. Astor,Deirdre De Vine,Garabed Eknoyan,Nathan W. Levin,Sally Burrows-Hudson,William F. Keane,Alan S. Kliger,Derrick Latos,Donna Mapes,Edith Oberley,Kerry Willis,George R. Bailie,Gavin J. Becker,Jerrilynn Burrowes,David Churchill,Allan J. Collins,William Couser,Dick DeZeeuw,Alan Garber,Thomas Golper,Frank A. Gotch,Antonio M. Gotto,Joel W. Greer,Richard H. Grimm,Ramon G. Hannah,Jaime Herrera Acosta,Ronald J. Hogg,Lawrence G. Hunsicker,Michael J. Klag,Saulo Klahr,Caya Lewis,Edmund G. Lowrie,Arthur J. Matas,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith Norris,William F. Owen,Thakor G. Patel,Glenda Payne,Rosa A. Rivera-Mizzoni,David A. Smith,Robert A. Star,Theodore Steinman,Fernando Valderrábano,John Walls,Jean Pierre Wauters,Nanette Wenger,Josephine P. Briggs +78 more
TL;DR: In the early 1990s, the National Kidney Foundation (K/DOQI) developed a set of clinical practice guidelines to define chronic kidney disease and to classify stages in the progression of kidney disease.
Journal ArticleDOI
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Elizabeta Nemeth,Marie S. Tuttle,Julie Powelson,Michael B. Vaughn,Adriana Donovan,Diane M. Ward,Tomas Ganz,Jerry Kaplan +7 more
TL;DR: It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
Journal ArticleDOI
KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease.
TL;DR: This chapter discusses clinical practice guidelines and recommendations for treatment of anemia in children and adults with Kidney Kidney disease, as well as specific cases of patients with HD-CKD.
Journal ArticleDOI
Revised European best practice guidelines for the management of anaemia in patients with chronic renal failure.
Francesco Locatelli,Pedro Aljama,Peter Bárány,Bernard Canaud,Fernando Carrera,Kai-Uwe Eckardt,Walter H. Hörl,Iain C Macdougal,Alison M. MacLeod,Andrzej Wiecek,Stewart Cameron +10 more
Journal ArticleDOI
Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency.
TL;DR: In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.