Journal ArticleDOI
Guideline for the laboratory diagnosis of functional iron deficiency.
TLDR
One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).Abstract:
Functional iron deficiency (FID) is a state in which there is insufficient iron incorporation into erythroid precursors in the face of apparently adequate body iron stores, as defined by the presence of stainable iron in the bone marrow together with a serum ferritin value within normal limits (Macdougall et al, 1989). In its broadest sense this definition encompasses the partial block in iron transport to the erythroid marrow seen in subjects with infectious, inflammatory and malignant diseases, and is a major component of the anaemia of chronic disease (ACD). One form of FID, found in some subjects treated with erythropoiesis-stimulating agents (ESAs), has been the subject of numerous studies following the widespread use of these agents, especially in subjects with chronic kidney disease (CKD).read more
Citations
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Journal ArticleDOI
Iron-deficiency anemia.
TL;DR: A review of the global nature of the disease, iron homeostasis in normal and iron-deficient states, clinical findings, treatment, and causes of iron-resistant iron deficiency is given in this article.
Journal ArticleDOI
Iron deficiency anaemia
TL;DR: The clinical presentation, epidemiology, pathophysiology, diagnosis, and acute management of iron deficiency anaemia, and outstanding research questions for treatment are discussed.
Journal ArticleDOI
Biomarkers of Nutrition for Development (BOND)-Iron Review.
Sean Lynch,Christine M. Pfeiffer,Michael K. Georgieff,Gary M. Brittenham,Susan J. Fairweather-Tait,Richard F. Hurrell,Harry J. McArdle,Daniel J Raiten +7 more
TL;DR: A full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers and their interpretation across a range of clinical and population-based uses are provided.
Journal ArticleDOI
International consensus statement on the peri-operative management of anaemia and iron deficiency.
Manuel Muñoz,Austin G. Acheson,M Auerbach,Martin Besser,O Habler,Henrik Kehlet,Giancarlo M. Liumbruno,Sigismond Lasocki,Patrick Meybohm,R. Rao Baikady,Toby Richards,Aryeh Shander,C. So‐Osman,Donat R. Spahn,Andrea Klein +14 more
TL;DR: A diagnostic approach for anaemia and iron deficiency in surgical patients; identification of patients appropriate for treatment; and advice on practical management and follow‐up are developed.
Journal ArticleDOI
Iron deficiency anaemia revisited
TL;DR: This review provides recent updates and guidance on the diagnosis and management of iron deficiency anaemia in multiple clinical settings.
References
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Journal ArticleDOI
Hemosiderosis in Hemodialysis Patients
TL;DR: The authors of the article "Hemosiderosis in Hemodialysis Patients: An Autopsy Study of 50 Cases" failed to emphasize that reticuloendothelial system iron overload without bone marrow iron overload occurred exclusively in those hemodialysis patients who had received iron parenterally.
Journal ArticleDOI
Association Between Transferrin Receptor–Ferritin Index and Conventional Measures of Iron Responsiveness in Hemodialysis Patients
TL;DR: TfR-F index is a new and surrogate marker to estimate body iron stores and guide IVFE therapy for long-term HD patients and is superior to routine tests for predicting response to IVFE supplementation in long- term HD patients.
Journal ArticleDOI
Elevated zinc protoporphyrin associated with thalassemia trait and hemoglobin E
TL;DR: The ZPP/H ratio is elevated in common hereditary hemoglobin disorders that mimic the microcytic anemia of iron deficiency, even in individuals without associated nutritional iron deficiency.
Journal ArticleDOI
Reticulocyte hemoglobin equivalent: an indicator of reduced iron availability in chronic kidney diseases during erythropoietin therapy.
Mariagrazia Garzia,Antonella Di Mario,Elisabetta Ferraro,Luigi Tazza,Elena Rossi,Giovanna Luciani,Gina Zini +6 more
TL;DR: This study showed an excellent diagnostic efficiency of RET-He to evaluate patients needing iron support and demonstrated a strict correspondence between the classic CHr and the new Ret-He, which could be used soon to guide and monitor iron treatment in dialysis patients.
Journal Article
The influence of plasma bilirubin on zinc protoporphyrin measurement by a hematofluorimeter.
Buhrmann E,Mentzer Wc,Lubin Bh +2 more
TL;DR: Direct measurement of ZPP by this fluorimeter yielded significantly higher levels than did an alternate extraction method, and photodegradation of bilirubin in whole blood samples did not decrease fluorescent interference.